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ProteomicsMycobacterium tuberculosis H2S functions as a sink to modulate central metabolism, bioenergetics, and drug susceptibility
H2S is a potent gasotransmitter in eukaryotes and bacteria. Host-derived H2S was shown to profoundly alter M. tuberculosis (Mtb) energy metabolism and growth. However, compelling evidence for endogenous production of H2S and its role in Mtb physiology is lacking. We show that multi-drug-resistant...
ORGANISM(S): Mycobacterium tuberculosis H37Rv_2009 
2021-08-16 | PXD022969 | Pride
Mycobacterium tuberculosis H2s 
TranscriptomicsHydrogen sulfide stimulates Mycobacterium tuberculosis respiration and growth to exacerbate TB disease
The aim of this experiment was to determine how exposure of Hydrogen sulfide impacts gene expression in Mycobacterium tuberculosis. RNA was isolated from actively growing mycobacterial cells (0.6-0.8 OD600) using Trizol according to established protocols (27). Briefly, cells were exposed to 25 µM G...
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2020-01-04 | E-MTAB-7421 | biostudies-arrayexpress
TranscriptomicsTranscritpome analysis of Mycobacterium tuberculosis (Mtb) mutants deficient in ergothioneine, or mycothiol production
This experiment was performed to determine deferentially regulated genes in the absence of redox buffer ergothioneine (EGT), or mycothiol (MSH). We had used two Mtb mutants namely egtA:Tn and egtD:Tn which are deficient in EGT production ( Transposon Mutant of EGT biosynthesis pathway); In additi...
ORGANISM(S): Mycobacterium tuberculosis CDC1551 
2016-01-27 | E-MTAB-4099 | biostudies-arrayexpress
UnknownNETosis associates with human TB lung tissue destruction and disease pathogenesis
Not available
S-SCDT-10_1038-S44321-026-00435-3 | biostudies-other
UnknownDual inhibition of the terminal oxidases eradicates antibiotic-tolerant Mycobacterium tuberculosis
Not available
S-SCDT-EMM-2020-13207 | biostudies-other
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