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ProteomicsMceC affinity purification and interactome analysis
Anti-FLAG affinty purification of mitochondria isolated from tetracycline inducible HEK293 cells expressing MceC-3XFLAG or control (EV) cells. Equal amounts of mitochondrial protein were solubilised and anti-FLAG immunoprecipitation performed.
ORGANISM(S): Homo sapiens (Human) Coxiella burnetii 
2020-11-12 | PXD019417 | Pride
Coxiella burnetii Effector protein Mitochondria 
ProteomicsLegionella effector LpPIP recruits protein phosphatase 1 to the mitochondria to induce dephosphorylation of outer membrane proteins
Legionella pneumophila utilises a type IVB secretion system (T4SS) to translocate over 300 effectors into host cells, hijacking cellular processes, including those within the mitochondrion. Currently, no Legionella effectors have been identified at the mitochondrial outer membrane, a critical interf...
ORGANISM(S): Homo sapiens (Human) 
2025-06-03 | PXD057005 | Pride
Mitochondrial outer membrane Protein phosphatase 1 Legionella pneumophila Effector proteins Mitochondria Tail-anchored protein Rvxf motif Type ivb secretion system 
ProteomicsImpaired protein import drives mitochondrial dysfunction upon mutation of TIMM50 in mitochondrial disease
TIMM50 is a core subunit of the TIM23 complex, the mitochondrial inner membrane translocase responsible for the import of presequence-containing precursors into the matrix or inner membrane. Here we describe a mitochondrial disease patient that is homozygous for a novel variant in TIMM50 and establi...
ORGANISM(S): Homo sapiens (Human) 
2024-07-03 | PXD047774 | Pride
Mitochondrial protein import Tim23 complex Mitochondria Timm50 Mitochondrial disease 
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