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ProteomicsTET1 interactome in mESCs (via ChIP-MS)
Precise regulation of DNA methylation in mammals is critical for genome stability and epigenetic regulation. The discovery of the ten-eleven translocation (TET) proteins catalyzing the oxidation from 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcyto...
ORGANISM(S): Mus musculus (Mouse) 
2022-08-31 | PXD028850 | Pride
Epigenetics Tet1 Mouse embryonic stem cells Dna methylation 
ProteomicsDistinct and stage-specific contributions of TET1 and TET2 to stepwise cytosine oxidation in the transition from naive to primed pluripotency
Cytosine DNA bases can be methylated by DNA methyltransferases and subsequently oxidized by TET proteins. The resulting 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC) are considered demethylation intermediates as well as stable epigenetic marks. To dissect the ...
ORGANISM(S): Mus musculus (Mouse) 
2020-07-24 | PXD019514 | Pride
Epigenetics Epiblast-like cells Mouse embryonic stem cells Dna methylation 
ProteomicsDissection of TET1 catalytic and non-catalytic functions reveals DNA demethylation independent gene and ERV regulation
Surveillance of DNA methylation in mammals is critical for genome stability and epigenetic regulation. The discovery of the ten-eleven translocation (TET) proteins catalyzing the oxidation from 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (...
ORGANISM(S): Mus musculus (Mouse) 
2022-08-11 | PXD028566 | Pride
Methylation Acetylation Tet1 Histone ptms 
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