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MetabolomicsGut Microbiome and Metabolome Signatures in Calcium Oxalate Stone Recurrence: A Multi-Omics Study

Background: The incidence and recurrence rate of nephrolithiasis have been increasing annually. Recent evidence highlights a close association between the composition and function of the gut microbiome and the occurrence and recurrence of kidney stones. We performed a multi-omic study to investig...

2026-03-03 | MTBLS13960 | MetaboLights
ProteomicsCharacterizations of HSP90-interacting complex in renal cells using tandem affinity purification and its potential role in kidney stone formation
Heat shock protein 90 (HSP90) is a highly abundant molecular chaperone that interacts with many other intracellular proteins to regulate various cellular processes. However, compositions of the HSP90-interacting complex remain underinvestigated. This study thus aimed to characterize such complex in ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-12-17 | MSV000083252 | MassIVE
TranscriptomicsTranscription profiling of mouse Th1 T cell clone and anergic Th1 T cell clone made anergic by plate-bound anti-CD3 antibody
compare gene expression profiles between normal and anergic T cells and identify upregulated genes in anergic T cells Experiment Overall Design: RNA from normal Th1 T cell clone and anergic Th1 T cell clone made anergic by plate-bound anti-CD3 antibody were isolated and amplified for microarray anal...
ORGANISM(S): Mus musculus 
2008-06-14 | E-GEOD-5960 | biostudies-arrayexpress
ProteomicsUrinary proteins from stone formers promote calcium oxalate crystallization, growth and aggregation via oxidative modifications
Various urinary parameters have been used to determine kidney stone risk. However, almost all of the widely used lithogenic indices rely on urinary concentrations of small molecules/ions and pH. We hypothesized that urinary macromolecules (especially proteins) also play a critical role in determinin...
ORGANISM(S): Homo sapiens (Human) 
2026-03-09 | PXD050609 | Pride
Nephrolithiasis  oxidized protein  risk factor  stone modulator  urinary protein  urolithiasis 
ProteomicsSelective Transamination of N-Ends (STONE)
This study combined shotgun proteomics with selective transamination to identify proteins expressed by Jurkat T-cells in the resting state.
ORGANISM(S): Homo sapiens (Human) 
2022-02-28 | PXD009427 | Pride
Jurkat Shotgun proteomics Transamination Stone Lc-ms/ms 
ProteomicsIFN-γ-driven iNOS induction in macrophages mediates CAR T cell resistance in B cell lymphoma
Chimeric antigen receptor (CAR) T cell therapies have revolutionized B cell malignancy treatment, but subsets of patients with large B cell lymphoma (LBCL) experience primary resistance or relapse after CAR T cell treatment. To uncover tumor microenvironment (TME)-induced resistance mechanisms, we e...
ORGANISM(S): Mus musculus (Mouse) 
2026-05-30 | PXD079073 | Pride
Macrophages B cell lymphoma Interferon Inos Chimeric antigen receptor t cell 
ProteomicsIFN-γ-driven iNOS induction in macrophages mediates CAR T cell resistance in B cell lymphoma: Phosphoproteomics
Chimeric antigen receptor (CAR) T cell therapies have revolutionized B cell malignancy treatment, but subsets of patients with large B cell lymphoma (LBCL) experience primary resistance or relapse after CAR T cell treatment. To uncover tumor microenvironment (TME)-induced resistance mechanisms, we e...
ORGANISM(S): Mus musculus (Mouse) 
2026-05-30 | PXD079082 | Pride
Macrophages B cell lymphoma Interferon Inos Chimeric antigen receptor t cell 
ProteomicsProtective cellular mechanism of estrogen against kidney stone formation: A proteomics approach and functional validation
Kidney stone disease is influenced by multiple factors, including but not limited to age, gender, genetic background, hydration status, diet and drug. Regarding the gender, epidemiologic data across the world has shown that females at the reproductive age (15-49 years) have lower incidence/prevalenc...
ORGANISM(S): Canis familiaris (Dog) (Canis lupus familiaris) 
2019-09-09 | PXD014768 | Pride
Female Kidney stone Nephrolithiasis Gender  hormone Estradiol 
GenomicsICOS-mediated inactivation of the FOXO1 transcription factor in the differentiation of T follicular helper cells
T follicular helper (Tfh) cells constitute an essential cell type in the induction of antibodies. We report that CD4 T cells lacking Foxo1 almost uniformly became CXCR5int Tfh cells following immunization. Moreover, a Foxo1 loss-of-function complemented an Icos mutation allowing the appearance of Tf...
ORGANISM(S): Mus musculus 
2013-06-01 | E-GEOD-46525 | biostudies-arrayexpress
ProteomicsA blood-based multi-omic landscape for the molecular characterization of Kidney Stone Disease
We adopted high-throughput sequencing and mass spectrometry (MS) techniques in this study and carried out an integrative analysis of exosome proteome and DNA methylation data from blood samples of normal and Kidney stone disease patients to screen biomarkers.
ORGANISM(S): Homo Sapiens 
2023-08-10 | PXD044503 |
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