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TranscriptomicsRibosome profiling reveals pervasive and regulated stop codon readthrough in Drosophila melanogaster
Ribosomes can read through stop codons in a regulated manner, elongating rather than terminating the nascent peptide. Stop codon readthrough is essential to diverse viruses, and phylogenetically predicted to occur in a few hundred genes in Drosophila melanogaster, but the importance of regulated rea...
ORGANISM(S): Drosophila melanogaster 
2013-12-05 | E-GEOD-49197 | biostudies-arrayexpress
ProteomicsCodon Specific Readthrough as a Mechanism of BRCA2 Restoration in Acquired PARP Inhibitor and Chemotherapy Resistance
Alteration of the gene encoding BRCA2, a protein involved in homologous recombination (HR), by missense or nonsense mutations results in sensitivity of a subset of breast and ovarian cancers to platinating agents and poly(ADP-ribose) polymerase (PARP) inhibitors. Conversely, resistance to these agen...
ORGANISM(S): Homo sapiens (Human) 
2025-10-27 | PXD037989 | Pride
Translational readthrough Ovarian cancer Brca2 
GenomicsTranscriptome-wide investigation of stop codon readthrough in Saccharomyces cerevisiae
Transcriptome-wide investigation of stop codon readthrough in Saccharomyces cerevisiae
PRJNA683007 | ENA
GenomicsStop Codon Context Influences Genome-Wide Stimulation of Termination Codon Readthrough by Aminoglycosides [Dataset 4]
Stop Codon Context Influences Genome-Wide Stimulation of Termination Codon Readthrough by Aminoglycosides [Dataset 4]
PRJNA576652 | ENA
GenomicsStop Codon Context Influences Genome-Wide Stimulation of Termination Codon Readthrough by Aminoglycosides [Dataset 2]
Stop Codon Context Influences Genome-Wide Stimulation of Termination Codon Readthrough by Aminoglycosides [Dataset 2]
PRJNA576650 | ENA
GenomicsStop Codon Context Influences Genome-Wide Stimulation of Termination Codon Readthrough by Aminoglycosides [Dataset 3]
Stop Codon Context Influences Genome-Wide Stimulation of Termination Codon Readthrough by Aminoglycosides [Dataset 3]
PRJNA576651 | ENA
ProteomicsReadthrough Events in Plants Reveal Unprecedented Plasticity of Stop Codons
Stop codon readthrough (SCR) has important biological implications but remains largely uncharacterized. Here, we identify 1,009 SCR events in plants using a proteogenomic strategy. Plant SCR candidates tend to have shorter transcript lengths and fewer exons and splice variants than non-SCR transcrip...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) Glycine max Zea mays (Maize) Oryza sativa (Rice) 
2024-02-02 | PXD035958 | Pride
Proteogenomics Mass spectrometry Stop codon readthrough Recoding plasticity Amino acids Plants 
ProteomicsReadthrough Events in Plants Reveal Unprecedented Plasticity of Stop Codons
Stop codon readthrough (SCR) has important biological implications but remains largely uncharacterized. Here, we identify 1,009 SCR events in plants using a proteogenomic strategy. Plant SCR candidates tend to have shorter transcript lengths and fewer exons and splice variants than non-SCR transcrip...
ORGANISM(S): Glycine max Arabidopsis thaliana (Mouse-ear cress) Zea mays (Maize) Oryza sativa (Rice) 
2024-02-02 | PXD038762 | Pride
Proteogenomics Mass spectrometry Stop codon readthrough Recoding plasticity Amino acids Plants 
GenomicsStop Codon Context Influences Genome-Wide Stimulation of Termination Codon Readthrough by Aminoglycosides [Dataset 1]
Stop Codon Context Influences Genome-Wide Stimulation of Termination Codon Readthrough by Aminoglycosides [Dataset 1]
PRJNA576649 | ENA
GenomicsStop Codon Context Influences Genome-Wide Stimulation of Termination Codon Readthrough by Aminoglycosides [Dataset 5]
Stop Codon Context Influences Genome-Wide Stimulation of Termination Codon Readthrough by Aminoglycosides [Dataset 5]
PRJNA576653 | ENA
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