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ProteomicsHuman SMARCA5 interactome in transgenic SMARCA5 mouse model
We hypothesize that the ISWI ATPase Smarca5 plays a role in hematopoietic stem cell development via its interaction partners, and to study the role, we used a mouse model with transgenic expression of SMARCA5 coupled with mass spectrometry analysis. The study uses transgenic SMARCA5 mouse model with...
ORGANISM(S): Mus musculus (Mouse) 
2024-06-22 | PXD049034 | Pride
Smarca5 Transgenic mice Immunoprecipitation 
TranscriptomicsRNA-seq of Smarca5-deficient CD4/CD8 double-positive thymocytes isolated from 6-week mouse thymi and their comparison with wild-type and TP53-null controls.
Here we utilized a conditional knock-out mouse model to investigate the role of Smarca5, an ISWI subfamily chromatin remodeling ATPase, during thymocyte development using hCD2-iCre transgene. We did transcriptional profiling of FACS-sorted CD4/CD8 double-positive thymocytes as this thymic population...
ORGANISM(S): Mus musculus 
2019-04-01 | E-MTAB-7758 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse Dnmt3L+/- sires compared to offspring of Dnmt3L+/+ sires to investigate the effect of paternal haploinsufficiency for Dnmt3L
There is increasing evidence that epigenetic information can be inherited across generations in mammals, despite extensive reprogramming both in the gametes and the early developing embryo. One corollary to this is that disruption of the establishment of epigenetic state in the gametes of a parent, ...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-7384 | biostudies-arrayexpress
ProteomicsDifferential requirements for Smarca5 expression during hematopoietic stem cell commitment.
The formation of hematopoietic cells relies on the chromatin remodeling activities of ISWI ATPase SMARCA5 (SNF2H) and its complexes. The Smarca5 null and conditional alleles have been used to study its functions in embryonic and organ development in mice. These mouse model phenotypes vary from embry...
ORGANISM(S): Homo Sapiens Mus Musculus 
2025-10-27 | PXD048865 | panorama
TranscriptomicsMouse P10 cerebellum: Smarca5 conditional KO mice (cKO) versus wild type controls
Gene expression profiling of mouse cerebellum in which the experimental strain conditionally lack the Smarca5 gene that encodes for the catalytic subunit of multiple chromatin remodeling complexes. Deletion of Smarca5 was restricted to those cells expressing Cre-recombinase driven by the Nestin prom...
ORGANISM(S): Mus musculus 
2014-04-30 | E-GEOD-42370 | biostudies-arrayexpress
TranscriptomicsMouse P0 cerebellum: Smarca5 conditional KO mice (cKO) versus wild type controls
Gene expression profiling of mouse cerebellum in which the experimental strain conditionally lack the Smarca5 gene that encodes for the catalytic subunit of multiple chromatin remodeling complexes. Deletion of Smarca5 was restricted to those cells expressing Cre-recombinase driven by the Nestin prom...
ORGANISM(S): Mus musculus 
2014-04-30 | E-GEOD-42369 | biostudies-arrayexpress
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