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UnknownSleep Apnea and Nocturnal Cardiac Arrhythmia: A Populational Study.
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S-EPMC4262096 | biostudies-literature
TranscriptomicsIn vitro and in vivo evidences of osteocytes involvement in myeloma-induced osteoclast formation and bone disease
The involvement of osteocytes in multiple myeloma (MM)-induced osteoclast formation and the occurrence of bone lesions are still unknown. Osteocytes regulate bone remodeling at least in part through the cell death and apoptosis triggering osteoclast recruitment and formation. In this study, firstly ...
ORGANISM(S): Homo sapiens 
2012-05-21 | E-GEOD-27372 | biostudies-arrayexpress
TranscriptomicsBone Marrow Monocyte/Macrophage Derived Activin A Mediates the Osteoclastogenic Effects of IL-3 in Myeloma
Myeloma bone disease is characterized by tremendous bone destruction with suppressed bone formation. IL-3 is a multifunctional cytokine that increases myeloma cell growth and osteoclast proliferation while inhibiting osteoblast differentiation. While IL-3 appears to be an attractive therapeutic targ...
ORGANISM(S): Homo sapiens 
2014-11-01 | E-GEOD-41992 | biostudies-arrayexpress
TranscriptomicsLenalidomide and Pomalidomide inhibit Multiple Myeloma-induced osteoclast formation and RANKL/OPG ratio in myeloma microenvironment targeting the expression of adhesion molecules.
Multiple myeloma (MM)-induced osteoclast (OC) formation occurs in close contact with MM cell infiltration into the bone marrow (BM) due to the imbalance of the receptor activator of NF-kappa-B ligand (RANKL)/osteoprotegerin (OPG) ratio in favor of RANKL in the micorenvironment. Soluble factors inclu...
ORGANISM(S): Homo sapiens 
2013-04-13 | E-GEOD-37302 | biostudies-arrayexpress
TranscriptomicsHypoxia-inducible factor (Hif)-1 knockdown blocks tumor growth, myeloma-induced angiogenesis and bone destruction in vivo
In multiple myeloma (MM), hypoxia-inducible transcription factor-1 (HIF-1) is overexpressed in the MM cells of the hypoxic bone marrow (BM) microenvironment. Herein, we explored in MM cells the in vitro and in vivo effects of persistent HIF-1 inhibition by expression of a lentivirus shRNA pool on pr...
ORGANISM(S): Homo sapiens 
2013-04-01 | E-GEOD-40326 | biostudies-arrayexpress
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