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TranscriptomicsTranscriptional response on ccw12 mutant from S. cerevisiae
Ccw12p is a cell surface mannoprotein required for cell wall stability. To investigate the compensation mechanism after CCW12 deletion we analysed the global gene expression in ccw12 mutant cells. SEY6210 and MEY12A (SEY6210 deleted for CCW12) yeast strains were growth on YPD medium supplemented wit...
ORGANISM(S): Saccharomyces cerevisiae 
2011-03-16 | E-GEOD-22649 | biostudies-arrayexpress
ProteomicsGlycosyltransferase POMGnT1 deficiency affects N-cadherin-mediated cell-cell adhesion
Deficiencies in the protein O-mannose β1,2-N-acetylglucosaminyltransferase 1 (POMGNT1), a glycosyltransferase involved in the elongation of classic O-mannosyl glycans, are mainly associated with muscle-eye-brain disease (MEB), a genetically heterogeneous congenital muscular dystrophy with brain and ...
ORGANISM(S): Homo sapiens (Human) 
2021-02-18 | PXD021321 | Pride
Pomgnt1 Pmgt1 Protein o-linked-mannose beta-1 2-n-acetylglucosaminyltransferase 1 Meb Pomgnt1 Mannosylation Muscular dystrophy-dystroglycanopathy Muscle-eye-brain disease Pomgnt1 
ProteomicsTruncated N-glycans destabilize POMT1 and POMT2 but do not limit cellular O-mannosylation in HEK293 cells
Protein O-mannosylation is initiated by the ER-resident enzymes POMT1 and POMT2, both of which carry multiple N-glycans essential for proper folding and activity. Although congenital disorders of glycosylation type I (CDG-I) disrupt the early N-glycosylation process, their impact on POMT biogenesis ...
ORGANISM(S): Homo Sapiens 
PXD073179 | panorama
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