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ProteomicsThrombospondin repeats secreted by C-mannosyltransferase-deficient mammalian cells
C-mannosylation in addition to N- and O-glycosylation is a further but less well studied type of protein glycosylation taking place in the endoplasmic reticulum (ER) characterised by the modification of tryptophan residues with a single mannose effecting protein folding, secretion and/or function. M...
ORGANISM(S): Homo sapiens (Human) 
2021-06-17 | PXD024192 | Pride
Thbs1 Dpy19l3 Adamts16 C-mannosylation Dpy19l1 Tsr 
ProteomicsTruncated N-glycans destabilize POMT1 and POMT2 but do not limit cellular O-mannosylation in HEK293 cells
Protein O-mannosylation is initiated by the ER-resident enzymes POMT1 and POMT2, both of which carry multiple N-glycans essential for proper folding and activity. Although congenital disorders of glycosylation type I (CDG-I) disrupt the early N-glycosylation process, their impact on POMT biogenesis ...
ORGANISM(S): Homo sapiens (Human) 
2026-08-02 | PXD073937 | Pride
Alg3  pomt1  pomt2  kiaa1549  n-glycosylation  o-mannosylation 
ProteomicsKIAA1549-BRAF O-mannosylation in mNSC cells
O-Mannosylation in h9 mouse neuronal stem cells (mNSC) explored by differential O-Man glycoproteomics and BC2L-A lectin affinity chomatography
ORGANISM(S): Mus musculus (Mouse) 
2026-08-02 | PXD062030 | Pride
Kiaa1549 O-mannosylation 
ProteomicsSecretome analysis of C-mannosyltransferase-deficient hiPSCs
C-mannosylation is a modification of tryptophan residues with a single mannose effecting protein folding, secretion and/or function. To date, only few proteins have been proven to be C-mannosylated and studies aiming at global assessment of protein C-mannosylation from cells or tissues are scarce. I...
ORGANISM(S): Homo sapiens (Human) 
2021-06-17 | PXD024193 | Pride
Hipscs Dpy19l3 Secretomics Dpy19l1 Tsr C-mannosylation 
GenomicsTargeting Mannosylation of Nicastrin N-glycans Attenuates γ-Secretase Activity and Notch-dependent Leukemia Progression
Targeting Mannosylation of Nicastrin N-glycans Attenuates γ-Secretase Activity and Notch-dependent Leukemia Progression
PRJNA1428773 | ENA
UnknownProtein O-mannosylation in metazoan organisms.
Not available
S-EPMC3984005 | biostudies-literature
UnknownO-Mannosylation and human disease.
Not available
S-EPMC3984002 | biostudies-literature
TranscriptomicsTargeting Mannosylation of Nicastrin N-glycans Attenuates γ-Secretase Activity and Notch-dependent Leukemia Progression
γ-Secretase is a transmembrane protease complex that cleaves multiple type I transmembrane proteins, including amyloid precursor protein and NOTCH. Although numerous γ-secretase inhibitors and modulators targeting Notch-dependent cancers have been developed in recent decades, their clinical translat...
ORGANISM(S): Homo sapiens 
2026-07-06 | GSE320527 | GEO
ProteomicsTryptophan C-mannosylation is critical for Plasmodium falciparum transmission Dataset1
C-mannosylation stabilizes proteins bearing a thrombospondin repeat (TSR) domain in metazoans. Here we show that Plasmodium falciparum expresses a DPY19 C-mannosyltransferase in the endoplasmic reticulum and that DPY19-deficiency abolishes C-glycosylation, destabilizes members of the TRAP adhesin fa...
ORGANISM(S): Plasmodium falciparum 
2022-07-06 | PXD033470 | Pride
Glycosylation Plasmodium falciparum Ookinete Sporozoite Gametocyte Gamete Dpy19 Transmission 
ProteomicsA suite of tools for the study of tryptophan C-mannosylation - additional point mutants
Tryptophan C-mannosylation is an unusual co-translational protein modification performed by metazoans and apicomplexan parasites. The prevalence of this modification and its biological function is poorly understood, with progress being hampered by a dearth of tools for its study. Here, we engineer o...
ORGANISM(S): Homo sapiens (Human) 
2020-11-16 | PXD021612 | Pride
Glycosylation C-mannosylation 
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