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ProteomicsProteomics reveals the regulation of lentivirus-mediated THBS1 overexpression in ALG1 and its mechanism in meibomian gland carcinoma
Meibomian gland carcinoma (MGC) is an aggressive and poorly prognostic eyelid malignancy. Previous studies have demonstrated that miR-3907 is highly expressed in MGC, accelerating tumor progression by negatively regulating THBS1. This study delves into the downstream regulatory mechanisms of THBS1. ...
ORGANISM(S): Homo sapiens (Human) 
2025-09-29 | PXD059655 | Pride
4d-label-free proteomics meibomian gland carcinoma thrombospondin-1 chitobiosyldiphosphodolichol beta-mannosyltransferase 
GenomicsRadiosensitizing effect of THBS1 knockdown in radioresistant head and neck carcinoma cell lines
Radiosensitizing effect of THBS1 knockdown in radioresistant head and neck carcinoma cell lines
PRJNA1306054 | ENA
ProteomicsQuantitative proteomics of the lung in a Thbs1 cell specific knockout model after pseudomonal injury in mice
An early event after lung injury is extracellular matrix (ECM) remodeling and the formation of a provisional matrix. While megakaryocytes (Mgks) and platelets play important roles in hemostasis, their impact on the matrix in lung injury is not fully understood. We utilized quantitative proteomics to...
ORGANISM(S): Mus musculus (Mouse) 
2026-02-20 | PXD071231 | Pride
TranscriptomicsRadiosensitizing effect of THBS1 knockdown in radioresistant head and neck carcinoma cell lines
This study aimed to investigate the radiosensitizing effects of THBS1 knockdown in radioresistant head and neck squamous cell carcinoma (HNSCC) cell lines. Using siRNA-mediated silencing of THBS1 in CAL27 and Detroit 562 cells, we examined transcriptomic changes associated with enhanced sensitivity ...
ORGANISM(S): Homo sapiens 
2025-08-21 | GSE305473 | GEO
UnknownStem cell therapy targets THBS1 to reverse endometrial fibrosis.
Not available
S-EPMC12916671 | biostudies-literature
UnknownTHBS1 mediates hypoxia driven EndMT in pulmonary hypertension.
Not available
S-EPMC11615509 | biostudies-literature
UnknownThbs1 induces lethal cardiac atrophy through PERK-ATF4 regulated autophagy.
Not available
S-EPMC8225674 | biostudies-literature
GenomicsTHBS1 Induces Dysfunction of Ovarian Granulosa Cells in Patients with Polycystic Ovary Syndrome by Activating the TGF-β/Smad Pathway
THBS1 Induces Dysfunction of Ovarian Granulosa Cells in Patients with Polycystic Ovary Syndrome by Activating the TGF-β/Smad Pathway
PRJNA1465726 | ENA
ProteomicsO-fucosylation of Thrombospondin Type I Repeats on Thrombospondin 1 is dispensable for trafficking to Platelets
Thrombospondin 1 (THBS1) is a secreted extracellular matrix glycoprotein that regulates a variety of cellular and physiological processes. THBS1’s diverse functions are attributed to interactions between the modular domains of THBS1 with an array of proteins found in the extracellular matrix. THBS1’...
ORGANISM(S): Mus musculus (Mouse) 
2023-02-02 | PXD037158 | Pride
Pofut2/o-fucosylation/c-mannosylation/thrombospondin 1/protein trafficking 
UnknownGenetic regulation of THBS1 methylation in diabetic retinopathy.
Not available
S-EPMC9702561 | biostudies-literature
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