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ProteomicsThrombospondin repeats secreted by C-mannosyltransferase-deficient mammalian cells
C-mannosylation in addition to N- and O-glycosylation is a further but less well studied type of protein glycosylation taking place in the endoplasmic reticulum (ER) characterised by the modification of tryptophan residues with a single mannose effecting protein folding, secretion and/or function. M...
ORGANISM(S): Homo sapiens (Human) 
2021-06-17 | PXD024192 | Pride
Thbs1 Dpy19l3 Adamts16 C-mannosylation Dpy19l1 Tsr 
ProteomicsA suite of tools for the study of tryptophan C-mannosylation - additional point mutants
Tryptophan C-mannosylation is an unusual co-translational protein modification performed by metazoans and apicomplexan parasites. The prevalence of this modification and its biological function is poorly understood, with progress being hampered by a dearth of tools for its study. Here, we engineer o...
ORGANISM(S): Homo sapiens (Human) 
2020-11-16 | PXD021612 | Pride
Glycosylation C-mannosylation 
ProteomicsSecretome analysis of C-mannosyltransferase-deficient hiPSCs
C-mannosylation is a modification of tryptophan residues with a single mannose effecting protein folding, secretion and/or function. To date, only few proteins have been proven to be C-mannosylated and studies aiming at global assessment of protein C-mannosylation from cells or tissues are scarce. I...
ORGANISM(S): Homo sapiens (Human) 
2021-06-17 | PXD024193 | Pride
Hipscs Dpy19l3 Secretomics Dpy19l1 Tsr C-mannosylation 
ProteomicsA suite of tools for the study of tryptophan C-mannosylation
Tryptophan C-mannosylation is a co-translational modification unique to the metazoans and apicomplexan parasites. It is the only example of protein C-glycosylation reported to date and appears to play a role in protein folding, trafficking and/or stability. Our knowledge of the prevalence of this mo...
ORGANISM(S): Homo sapiens (Human) 
2020-11-16 | PXD018401 | Pride
Lc-ms Glycosylation C-mannosylation 
UnknownProtein C-Mannosylation and C-Mannosyl Tryptophan in Chemical Biology and Medicine.
Not available
S-EPMC8433626 | biostudies-literature
UnknownIdentification of C-mannosylation in a receptor tyrosine kinase AXL.
Not available
S-EPMC11632359 | biostudies-literature
UnknownTryptophan C-mannosylation is critical for Plasmodium falciparum transmission.
Not available
S-EPMC9338275 | biostudies-literature
UnknownC-mannosylation supports folding and enhances stability of thrombospondin repeats.
Not available
S-EPMC6954052 | biostudies-literature
ProteomicsTryptophan C-mannosylation is critical for Plasmodium falciparum transmission Dataset1
C-mannosylation stabilizes proteins bearing a thrombospondin repeat (TSR) domain in metazoans. Here we show that Plasmodium falciparum expresses a DPY19 C-mannosyltransferase in the endoplasmic reticulum and that DPY19-deficiency abolishes C-glycosylation, destabilizes members of the TRAP adhesin fa...
ORGANISM(S): Plasmodium falciparum 
2022-07-06 | PXD033470 | Pride
Glycosylation Plasmodium falciparum Ookinete Sporozoite Gametocyte Gamete Dpy19 Transmission 
UnknownC-Mannosylation Enhances the Structural Stability of Human RNase 2.
Not available
S-EPMC7399192 | biostudies-literature
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