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MetabolomicsPlasmodium falciparum adapts its investment into replication versus transmission according to the host environment

The malaria parasite life cycle includes asexual replication in human blood, with a proportion of parasites differentiating to gametocytes required for transmission to mosquitoes. Commitment to differentiate into gametocytes, which is marked by activation of the parasite transcription factor ...

2025-07-09 | MTBLS5130 | MetaboLights
MetabolomicsRepurposing the orphan drug nitisinone to control the transmission of African trypanosomiasis
Tsetse transmit African trypanosomiasis, which is a disease fatal to both humans and animals. A vaccine to protect against this disease does not exist so transmission control relies on eliminating tsetse populations. Although neurotoxic insecticides are the gold standard for insect control, they neg...
2021-10-06 | MTBLS2166 | MetaboLights
MetabolomicsLimited vertical transmission but profound immune dysregulation at the maternal-fetal interface after SARS-CoV-2 infection

The endemic of SARS-CoV-2 underscores the imperative to elucidate its effects on pregnancy, particularly regarding the potential for vertical transmission and its influence on the early maternal-fetal interface, which remain insufficiently defined. To address this, we performed an extensive cohor...

2026-03-05 | MTBLS13103 | MetaboLights
Genomicstransmission
Microbiota transmission
PRJEB28216 | ENA
ProteomicsProteomic analysis of various Bemisia tabaci population with variable TYLCV transmission abilities
Begomoviruses, the largest, most damaging and emerging group of plant viruses in the world, infect hundreds of plant species and new virus species of the group are discovered each year. They are transmitted by species of the whitefly Bemisia tabaci. Tomato yellow leaf curl virus (TYLCV) is one of th...
ORGANISM(S): Bemisia tabaci 
2020-10-26 | PXD016964 | Pride
Bemisia tabaci Tylc Transmission Bacterial symbiont 
TranscriptomicsTranscription profiling of human HIV-1 infection and perinatal transmission in Botswana
We used Affymetrix U133A 2.0 chips to better understand transcriptional changes associated with HIV-1 infection and perinatal transmission in human PBMCS obtained from young adult mothers with infants in Botswana in vivo. HIV seropositive and drug naïve samples:; GSM94333, GSM94334, GSM94335, GSM9...
ORGANISM(S): Homo sapiens 
2008-06-12 | E-GEOD-4124 | biostudies-arrayexpress
ProteomicsIntercellular Transmission of a Synthetic Bacterial Cytotoxic Prion-Like Protein in Mammalian Cells.
bacterial amyloidosis, prion-like, RepA-WH1, intercellular transmission,proteotoxic cross-aggregation
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2020-05-26 | PXD018245 | Pride
Bacterial amyloidosis Repa-wh1 Prion-like Intercellular transmission Proteotoxic cross-aggregation 
TranscriptomicsCell cycle-dependent, intercellular transmission of Toxoplasma gondii is accompanied by marked changes in parasite gene expression.
Intracellular microbes have evolved efficient strategies for transitioning from one cell to another in a process termed intercellular transmission. Here we show that host cell transmission of the obligate intracellular parasite Toxoplasma gondii is closely tied to specific cell cycle distributions, ...
ORGANISM(S): Toxoplasma gondii 
2010-12-27 | E-GEOD-20480 | biostudies-arrayexpress
ProteomicsTryptophan C-mannosylation is critical for Plasmodium falciparum transmission Dataset1
C-mannosylation stabilizes proteins bearing a thrombospondin repeat (TSR) domain in metazoans. Here we show that Plasmodium falciparum expresses a DPY19 C-mannosyltransferase in the endoplasmic reticulum and that DPY19-deficiency abolishes C-glycosylation, destabilizes members of the TRAP adhesin fa...
ORGANISM(S): Plasmodium falciparum 
2022-07-06 | PXD033470 | Pride
Glycosylation Plasmodium falciparum Ookinete Sporozoite Gametocyte Gamete Dpy19 Transmission 
ProteomicsAMPA-receptor specific biogenesis complexes control synaptic transmission and intellectual ability
AMPA-type glutamate receptors (AMPARs), key elements in excitatory neuro-transmission in the brain, are macromolecular complexes whose properties and cellular functions are determined by the co-assembled constituents of their proteome. Here we identify AMPAR complexes that transiently form in the en...
ORGANISM(S): Mus musculus (Mouse) Rattus norvegicus (Rat) 
2018-10-17 | PXD006413 | Pride
Excitatory synaptic transmission Proteomic analysis Intellectual disability Ampa-receptor biogenesis complexes 
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