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ProteomicsSubstrate identification of ADAMTS16
Secreted and cell-surface proteases are major mediators of extracellular matrix remodelling, but their mechanisms and regulatory impact are poorly understood. We developed a mass spectrometry approach using cell free ECM produced by mouse Balb/c 3T3 cells in vitro to identify fibronectin as a novel ...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2018-04-23 | PXD007284 | Pride
Adamts16 Fibronectin Lc-ms/ms 
TranscriptomicsPositional identification of Adamts16 variants linked to inherited hypertension: knockdown of Adamts16 in NRK-52E cells
We used Affymetrix GeneChips to expression profile rat kidney NRK-52E cells treated with control scrambled siRNA or siRNA specifically targeting Adamts16. The goal of this project was to identify the downstream genes regulated by Adamts16 (the function of Adamts16 has yet to be fully delineated). Ge...
ORGANISM(S): Rattus norvegicus 
2008-11-01 | GSE12724 | GEO
TranscriptomicsTranscription profiling of rat Adamts16 variants linked to inherited hypertension: knockdown of Adamts16 in NRK-52E cells
We used Affymetrix GeneChips to expression profile rat kidney NRK-52E cells treated with control scrambled siRNA or siRNA specifically targeting Adamts16. The goal of this project was to identify the downstream genes regulated by Adamts16 (the function of Adamts16 has yet to be fully delineated). Ge...
ORGANISM(S): Rattus norvegicus 
2008-11-13 | E-GEOD-12724 | biostudies-arrayexpress
TranscriptomicsPositional identification of Adamts16 variants linked to inherited hypertension: gene expression of congenic vs S rats
We used Affymetrix GeneChips to expression profile kidneys from Dahl salt-senstive hypertensive inbred strain and less hypertensive S.LEW(D1MCO4x1x3Bx1) congenic strain to identify genes downstream of Adamts16 (the function of Adamts16 has yet to be fully delineated). The S.LEW(D1MCO4x1x3Bx1) congen...
ORGANISM(S): Rattus norvegicus 
2008-11-01 | GSE12725 | GEO
GenomicsExtracellular Matrix Disorganization Caused by ADAMTS16 Deficiency Leads to Bicuspid Aortic Valve with Raphe Formation
Extracellular Matrix Disorganization Caused by ADAMTS16 Deficiency Leads to Bicuspid Aortic Valve with Raphe Formation
PRJNA972722 | ENA
UnknownPositional identification of variants of Adamts16 linked to inherited hypertension.
Not available
S-EPMC2706685 | biostudies-literature
ProteomicsThrombospondin repeats secreted by C-mannosyltransferase-deficient mammalian cells
C-mannosylation in addition to N- and O-glycosylation is a further but less well studied type of protein glycosylation taking place in the endoplasmic reticulum (ER) characterised by the modification of tryptophan residues with a single mannose effecting protein folding, secretion and/or function. M...
ORGANISM(S): Homo sapiens (Human) 
2021-06-17 | PXD024192 | Pride
Thbs1 Dpy19l3 Adamts16 C-mannosylation Dpy19l1 Tsr 
UnknownInteraction between thyroglobulin and ADAMTS16 in premature ovarian failure.
Not available
S-EPMC4192452 | biostudies-literature
TranscriptomicsExtracellular Matrix Disorganization Caused by ADAMTS16 Deficiency Leads to Bicuspid Aortic Valve with Raphe Formation
BACKGROUND: A better understanding of the molecular mechanism of aortic valve development and bicuspid aortic valve (BAV) formation would significantly improve and optimize the therapeutic strategy for treating BAV patients. Over the past decade, the genes involved in aortic valve development and BA...
ORGANISM(S): Mus musculus 
2023-12-30 | GSE232560 | GEO
TranscriptomicsTranscription profiling of rat Adamts16 variants linked to inherited hypertension: gene expression of congenic vs S rats
We used Affymetrix GeneChips to expression profile kidneys from Dahl salt-senstive hypertensive inbred strain and less hypertensive S.LEW(D1MCO4x1x3Bx1) congenic strain to identify genes downstream of Adamts16 (the function of Adamts16 has yet to be fully delineated). The S.LEW(D1MCO4x1x3Bx1) congen...
ORGANISM(S): Rattus norvegicus 
2008-11-13 | E-GEOD-12725 | biostudies-arrayexpress
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