Sort   by:  
 Page size 
ProteomicsRif1 S-acylation mediates DNA double-strand break repair at the inner nuclear membrane
Rif1 is involved in telomere homeostasis, DNA replication timing, and DNA double-strand break (DSB) repair pathway choice from yeast to human. The molecular mechanisms that enable Rif1 to fulfill its diverse roles remain to be determined. Here, we demonstrate that Rif1 is S-acylated within its conse...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2019-04-15 | PXD012137 | Pride
Non-homologous end-joining Dna double-strand break repair Palmitoylation Yeast Rif1 s-acylation 
GenomicsPTIP promotes chromatin changes critical for immunoglobulin class switch recombination
Programmed genetic rearrangements in lymphocytes require transcription at antigen receptor genes to promote accessibility for initiating double-strand break (DSB) formation critical for DNA recombination and repair. Here we show that activated B cells deficient in the PTIP component of the MLL3 (mix...
ORGANISM(S): Mus musculus 
2010-08-25 | E-GEOD-20852 | biostudies-arrayexpress
UnknownAnalysis of Coinfections with A/H1N1 Strain Variants among Pigs in Poland by Multitemperature Single-Strand Conformational Polymorphism.
Not available
S-EPMC4413886 | biostudies-literature
UnknownNF-κB regulates DNA double-strand break repair in conjunction with BRCA1-CtIP complexes.
Not available
S-EPMC3245919 | biostudies-literature
TranscriptomicsS080_BrCaRes_Schneeweiss et al.
In patients with primary breast cancer, neoadjuvant chemotherapy with doxorubicin plus pemetrexed followed by docetaxel (AP-D) is associated with a pathologic complete response (pCR) rate of 16.5%, and doxorubicin plus cyclophosphamide followed by docetaxel (AC-D) is associated with a pCR rate of 20...
ORGANISM(S): Homo sapiens 
2014-02-01 | E-TABM-1186 | biostudies-arrayexpress
UnknownSCAI promotes DNA double-strand break repair in distinct chromosomal contexts.
Not available
S-EPMC5278951 | biostudies-literature
TranscriptomicsRecombination initiation maps of individual human genomes
DNA double-strand breaks (DSBs) are introduced in meiosis to initiate recombination and to generate crossovers, the reciprocal exchanges of genetic material between parental chromosomes. Here we present the first high-resolution map of meiotic DSBs in individual human genomes. Comparing DSB maps bet...
ORGANISM(S): Homo sapiens 
2014-11-17 | E-GEOD-59836 | biostudies-arrayexpress
TranscriptomicsQuantitative genome-wide enhancer activity maps for five Drosophila species show functional enhancer conservation and turnover during cis-regulatory evolution
Phenotypic differences between closely related species are thought to arise primarily from changes in gene expression due to mutations in cis-regulatory sequences (enhancers). However, it has remained unclear, how frequently mutations alter enhancer activity or create functional enhancers de novo. H...
ORGANISM(S): Drosophila willistoni 
2014-04-28 | E-GEOD-48251 | biostudies-arrayexpress
UnknownFunctional intersection of ATM and DNA-dependent protein kinase catalytic subunit in coding end joining during V(D)J recombination.
Not available
S-EPMC3753869 | biostudies-literature
TranscriptomicsChronic liver inflammation-induced double strand DNA breaks enhance hepatocarcinogenesis
Surgical resection is the preferred treatment for Hepatocellular carcinoma; however, it induces tumor recurrence. Our objective was to understand the molecular mechanisms linking liver regeneration under chronic-inflammation to tumorigenesis. Mdr2-knockout mice, a model of inflammation-associated ca...
ORGANISM(S): Mus musculus 
2010-01-03 | E-GEOD-14539 | biostudies-arrayexpress
Sort   by:  
 Page size