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TranscriptomicsJIL-1 RNAi in Drosophila S2 Cells
Profiling of changes in steady state RNA levels upon RNAi-mediated knockdown of the chromosomal kinase JIL-1 in Drosophila S2 cells. Drosophila S2 cells were incubated 7 days after treatment with 10 µg of dsRNA directed against GST/EGFP or JIL-1, respectively. 5 biological replicates per target have...
ORGANISM(S): Drosophila melanogaster 
2011-02-01 | E-GEOD-22620 | biostudies-arrayexpress
TranscriptomicsRNAi profiling of Drosophila SL2 cells knocked down for ISWI
Profiling of changes in steady state RNA levels upon RNAi-mediated knockdown of the nucleosome remodeling ATPase ISWI in Drosophila SL2 cells. Quantitation of the corresponding proteomes has been performed to describe transcriptome-proteome relations. The analysis indicates a limited correlation of ...
ORGANISM(S): Drosophila melanogaster 
2008-10-25 | E-GEOD-11164 | biostudies-arrayexpress
TranscriptomicsDifferential Chromatin Binding of the Drosophila Dosage Compensation Complex
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Drosophila melanogaster 
2012-12-11 | E-GEOD-37865 | biostudies-arrayexpress
TranscriptomicsIn utero caffeine exposure alters DNA methylation patterns in adult hearts
Our previous research demonstrated that caffeine exposure on embryonic day (E) 8.5 increased body weight, altered cardiac morphology and function in adult male mice. However, these adverse effects were not observed in adenosine A1 receptor knockout (A1AR-/-) mice. Our hypothesis is that A1AR action ...
ORGANISM(S): Mus musculus 
2015-12-19 | E-GEOD-43030 | biostudies-arrayexpress
TranscriptomicsChromosomal High Affinity Binding Sites for the Drosophila Dosage Compensation Complex.
We identified 131 high affinity sites of the Drosophila DCC combining residual ChIP-chip profiles after differential crosslinking and RNAi-mediated knockdown of spreading factors Keywords: ChIP-chip MSL1 and MSL2 ChIP under various conditions including differential crosslinking and RNAi against MOF...
ORGANISM(S): Drosophila melanogaster 
2008-12-13 | E-GEOD-12292 | biostudies-arrayexpress
GenomicsActive Promoters give rise to false positive 'Phantom Peaks' in ChIP-Seq experiments
We applied ChIP-seq to map the chromosomal binding sites for two nucleosome remodeling complexes containing the ATPase ISWI, ACF and RSF, in Drosophila embryos. Employing a panel of polyclonal and monoclonal antibodies directed against their signature subunits, ACF1 and RSF1, robust profiles were ob...
ORGANISM(S): Drosophila melanogaster 
2015-07-10 | E-GEOD-67323 | biostudies-arrayexpress
TranscriptomicsNeuroD1 reprograms chromatin and transcription factor landscapes to induce the neuronal program
Cell fate specification relies on the action of critical transcription factors that become available at distinct stages of embryonic development. One such factor is NeuroD1, which is essential for eliciting the neuronal development program and possesses the ability to reprogram other cell types into...
ORGANISM(S): Mus musculus 
2015-11-02 | E-GEOD-65072 | biostudies-arrayexpress
TranscriptomicsAnalysis of genome-wide binding of the insulator factors CTCF and CP190
We identified about 3000 CTCF sites in the genome. In addition to binding to CTCF sites we found CP190 to bind to transcriptional start sites of actively transcribed genes where it inversely correlates with nucleosome occupancy. Keywords: ChIP-chip CTCF and CP190 ChIP. 2 biological replicates per e...
ORGANISM(S): Drosophila melanogaster 
2010-05-05 | E-GEOD-12749 | biostudies-arrayexpress
TranscriptomicsSuv4-20h Histone Methyltransferases Promote Neuroectodermal Differentiation by Silencing the Pluripotency-Associated Oct-25 Gene
Post-translational modifications (PTMs) of histones exert fundamental roles in regulating gene expression. During development, groups of PTMs are constrained by unknown mechanisms into combinatorial patterns, which facilitate transitions from uncommitted embryonic cells into differentiated somatic c...
ORGANISM(S): Xenopus laevis 
2013-02-06 | E-GEOD-41256 | biostudies-arrayexpress
TranscriptomicsThe nucleosome remodeler SNF2L modulates WNT signaling for cellular homeostasis
ISWI is an evolutionary conserved ATPase that catalyzes nucleosome remodeling in several different complexes. Two mammalian ISWI orthologs, SNF2H and SNF2L, have specialized functions despite their high similarity. Due to the lack of reagents the functions of SN2L in human cells had not been establi...
ORGANISM(S): Homo sapiens 
2012-05-10 | E-GEOD-30471 | biostudies-arrayexpress
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