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Lab affiliation

1Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada 2Department of Molecular Genetics, University of Toronto, 1 King's College Circle, Toronto, Ontario M5S 1A8, Canada Departments of Biochemistry and Biology, Boston University, 71 E. Concord St, Boston, MA 02118, USA (2)
Department of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Crown Street, Liverpool, L69 3BX, UK (1)
School of Life Sciences, University of Dundee, Dow Street, Dundee, DD1 5EH, UK (1)

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A Cross-Platform Metabolomics Comparison Identifies Serum Metabolite Signatures of Liver Fibrosis Progression in Chronic Hepatitis C Patients

Metabolomics offers new insights into disease mechanisms that is enhanced when adopting orthogonal instrumental platforms to expand metabolome coverage, while also reducing false discoveries by independent replication. Herein, we report the first inter-method comparison when using multisegment injec...

2023-08-22 | MTBLS3111 | MetaboLights

Examining the effects of cigarette smoke on mouse lens through a multi OMIC approach

Here, we report a multi OMIC (transcriptome, proteome, and metabolome) approach to investigate molecular changes in lens fiber cells (FC) of mice exposed to cigarette smoke (CS). Pregnant mice were placed in a whole-body smoke chamber and a few days later pups were born, which were exposed to CS for...

2024-03-24 | MTBLS207 | MetaboLights

The phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 inhibitor 3PO is a modulator of neutrophil metabolism, ROS production and NET release

Neutrophils are key effector leukocytes of the innate immune system and play a pivotal role in defending the host against microbial infections. Recent studies have identified a crucial link between glycolysis and neutrophil cellular functions. We have investigated in human neutrophils, the intricate...

2025-08-14 | MTBLS6215 | MetaboLights

Diagnostic utility of clinicodemographic, biochemical and metabolite variables to identify viable pregnancies in a symptomatic cohort during early gestation.

Study question: Can a novel machine learning pipeline create predictive models that identify a composite biomarker to differentiate live normally sited pregnancies (LNSP) from non-viable pregnancies in women presenting with pain and/or bleeding in early gestation?

Summary answer: Serum met...

2025-08-14 | MTBLS6219 | MetaboLights

Frailty-Informed Pain Management: A Clinical Imperative Beyond Chronological Age.

Not available

S-EPMC12568795 | biostudies-literature

Eliciting Beliefs about COVID-19 Prevalence and Mortality: Epidemiological Models Compared with The Street.

Not available

S-EPMC8546055 | biostudies-literature

The secreted AdamTS-A metalloprotease is required for collective cell migration.

Not available

S-EPMC3631971 | biostudies-literature

Rapid isolation of a single-chain antibody against the cyanobacterial toxin microcystin-LR by phage display and its use in the immunoaffinity concentration of microcystins from water.