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TranscriptomicsPCR array of inflammatory cytokines and receptors in mouse lungs with NF-kappaB RelA mutant in alveolar epithelial cells during pneumococcal pneumonia
A murine model of RelA mutated throughout the alveolar epithelium was generated. Mice were anesthetized and intratracheally instilled with 106 CFU of Streptococcus pneumoniae serotype 3 into the left lung lobe. Mice were euthanized after 15 hours after instillation, and left lung lobes were collecte...
ORGANISM(S): Mus musculus 
2012-08-03 | E-GEOD-38399 | biostudies-arrayexpress
TranscriptomicsHepatic induction of cholesterol biosynthesis reflects a remote adaptive response to pneumococcal pneumonia
Transcriptional effects in liver, lung and blood samples from mice after intratracheal challenge with either Streptococcus pneumoniae serotype 19 (lobar-pneumonia) or serotype 2 (sepsis) were monitored after 6 and 24 hours and compared to sham (vehicle control). We gratefully acknowledge the BMBF gr...
ORGANISM(S): Mus musculus 
2011-01-10 | E-GEOD-26472 | biostudies-arrayexpress
TranscriptomicsGene expression in C57BL/6 mouse lungs after exposure to aerosolized NTHi lysate
Pneumonia is a serious problem worldwide. We recently demonstrated that innate defense mechanisms of the lung are highly inducible against pneumococcal pneumonia. To determine the breadth of protection conferred by stimulation of lung mucosal innate immunity, and to identify cells and signaling pa...
ORGANISM(S): Mus musculus 
2010-06-24 | E-GEOD-13740 | biostudies-arrayexpress
ProteomicsHost response to S. pneumoniae TIGR4 and ΔpotABCD
The aim of this experiment is to determine the difference in protein expression, if any, in a mouse model of pneumococcal pneumonia using wild type and a polyamine transport operon deletion mutant strain of S. pneumoniae TIGR4, using expression proteomics. Eight week old female C57bl/6 mice were use...
ORGANISM(S): Mus musculus (Mouse) 
2018-10-27 | PXD002300 | Pride
Lung Mouse Streptococcal pneumonia 
TranscriptomicsSynergistic Exacerbation of Oral Streptococci-induced pneumonia due to Prevotella intermedia
Anaerobic bacteria in the oral cavity can cause respiratory infections. However, their precise mechanisms of action remain elusive. Unexpectedly, bacterial flora analysis using 16s rRNA revealed ‘hidden’ mixed infections of anaerobic bacteria and commensal oral Streptococcus species in community-acq...
ORGANISM(S): Mus musculus 
2025-08-20 | GSE278151 | GEO
UnknownEpidemiology and Management of Pediatric Group A Streptococcal Pneumonia With Parapneumonic Effusion: An Observational Study.
Not available
S-EPMC11319078 | biostudies-literature
TranscriptomicsExpression data from mouse livers expressing or lacking Cre recombinase during pneumonia
Cre-recombinase expression under control of an albumin promoter in the presence of floxed alleles is a highly effective and specific way to target gene mutations in hepatocytes. However, some concerns have been raised regarding off-target and/or toxic effects of cre itself, possibly confounding the...
ORGANISM(S): Mus musculus 
2012-02-16 | E-GEOD-35515 | biostudies-arrayexpress
TranscriptomicsExpression data from mouse livers lacking STAT3 during pneumonia
A common response to physiological duress is the hepatic acute phase response, a process during which the expression of many genes is altered in the liver. Amongst these transcripts are those encoding acute phase proteins, defined as circulating proteins with significantly changed concentrations du...
ORGANISM(S): Mus musculus 
2012-02-16 | E-GEOD-35514 | biostudies-arrayexpress
TranscriptomicsThe clock gene BMAL1 inhibits macrophage motility, phagocytosis, and impairs defence against pneumonia
The circadian clock regulates many aspects of immunity. Bacterial infections are affected by time of day, but the mechanisms involved remain undefined. Here we show that loss of the core clock protein BMAL1 in macrophages confers protection against pneumococcal pneumonia. RNAseq was performed on per...
ORGANISM(S): Mus musculus 
2019-12-20 | E-MTAB-8411 | biostudies-arrayexpress
TranscriptomicsExpression data from mouse livers lacking NF-kappaB RelA (p65) during pneumonia
A common response to physiological duress is the hepatic acute phase response, a process during which the expression of many genes is altered in the liver. Amongst these transcripts are those encoding acute phase proteins, defined as circulating proteins with significantly changed concentrations du...
ORGANISM(S): Mus musculus 
2012-02-16 | E-GEOD-35513 | biostudies-arrayexpress
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