The clock gene BMAL1 inhibits macrophage motility, phagocytosis, and impairs defence against pneumonia
Ontology highlight
ABSTRACT: The circadian clock regulates many aspects of immunity. Bacterial infections are affected by time of day, but the mechanisms involved remain undefined. Here we show that loss of the core clock protein BMAL1 in macrophages confers protection against pneumococcal pneumonia. RNAseq was performed on peritoneal macrophages from wild type and BMAL1 knock out mice.
INSTRUMENT(S): Illumina HiSeq 4000
ORGANISM(S): Mus musculus
SUBMITTER: Leo Zeef
PROVIDER: E-MTAB-8411 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
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