Transcriptional profiling and functional characterization of Schistosoma japonicum-stimulated Alternatively Activated Macrophages

ABSTRACT: Alternatively activated macrophages (AAMφs) play important roles in a number of Th2 driven pathologies including asthma and allergy, and a number of parasitic infections. Our studies, and those of others, investigating the pathologies associated with infection with the helminth Schistosoma japonicum implicate a role for AAMφs in fibrosis and immunomodulation.. In the present study we show that S. japonicum-secreted egg antigens are able to induce the alternative activation of macrophages as characterised by the induction of Chi3l3 and Arg1 expression. Retnla, another common marker of AAMφs, was not consistently induced in these macrophages suggesting that the specific function of these cells may differ to those induced by S. mansoni and other parasites. Closer examination of the gene exp

ORGANISM(S): Mus musculus

SUBMITTER: Melissa Burke 

PROVIDER: E-GEOD-32621 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress