Migrating Schistosoma japonicum schistosomula induce type-2 inflammation in the murine lung

ABSTRACT: Migrating schistosomula are an important stage of the schistosome lifecycle and represent a key target for elimination of infection by natural and vaccine induced host immune responses. To gain a better understanding of how these parasites initiate a primary host immune response we have characterised the host lung response to migrating Schistosoma japonicum schistosomula using a combination of histochemistry, microarrays and quantitative cytokine analysis. Our data suggest that, during a S. japonicum infection, actively migrating schistosomula induce a Type-2 cytokine response in the lung that may support the subsequent development of a CD4+ T helper 2 (Th2) response against egg antigens. This hypothesis is supported by the fact that schistosomula and schistosome eggs are known to express

ORGANISM(S): Mus musculus

SUBMITTER: Melissa Burke 

PROVIDER: E-GEOD-27171 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress