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MetabolomicsArginine-induced metabolomic perturbation in Streptococcus mutans

BACKGROUND: Streptococcus mutans is a major pathogen responsible for dental caries. Arginine is a promising potential caries preventive agent which can inhibit the growth of S. mutans. However, the mechanism whereby arginine inhibits S. mutans growth r...

2023-10-20 | MTBLS3020 | MetaboLights
MetabolomicsThe Impacts of Sortase A and the 4'-Phosphopantetheinyl Transferase Homolog Sfp on Streptococcus mutans Extracellular Membrane Vesicle Biogenesis

Extracellular membrane vesicles (EMVs) are produced by many Gram-positive organisms, but information regarding vesiculogenesis is incomplete. We used single gene deletions to evaluate the impacts on Streptococcus mutans EMV biogenesis of Sortase A (SrtA), which affects S. mutans...

2021-10-06 | MTBLS1812 | MetaboLights
MetabolomicsRcrR: A Multifunctional Transcriptional Regulator Orchestrating the cariogenic virulence of Streptococcus mutans

We systematically investigated RcrR's contribution to cariogenic virulence using isogenic wild-type, DeltarcrR deletion mutant, and complemented strains. We assessed bacterial growth, biofilm architecture, acid tolerance, and H+-ATPase activity. To delineate the global regulatory network, we inte...

2026-08-06 | MTBLS15272 | MetaboLights
MetabolomicsStreptococcus mutans organic acids/amino acid profiles, effect of oxidative stress; pilot
Not available
ORGANISM(S): Streptococcus mutans 
ST000466 | MetabolomicsWorkbench
TranscriptomicsAcid-inducible genes in Streptococcus mutans: multiple two-component systems involved in acid adaptation
Global transcriptional analysis of acid-inducible genes in Streptococcus mutans: multiple two-component systems involved in acid adaptation pH is a major environmental factor that regulates gene expression in many bacteria. Streptococcus mutans in dental biofilms is regularly exposed to cycles of a...
ORGANISM(S): Streptococcus mutans 
2010-05-22 | E-GEOD-15125 | biostudies-arrayexpress
ProteomicsRemodeling of the Streptococcus mutans proteome in response to LrgAB and external stresses
This project investigates the changes in proteome profiles that occurred in the same set of S. mutans wild-type and lrgAB mutant samples used in our recently published RNA-seq study. To this end, mass spectrometry-based label-free quantitative proteomics, a technology known to enable comprehensive i...
ORGANISM(S): Streptococcus mutans UA159 
2018-10-24 | PXD006735 | Pride
Environment stress Label-free proteomics Streptococcus mutans 
TranscriptomicsStreptococcus mutans UA159 vs. spx mutant strains
Transcriptional profiling to investigate the regulatory roles of SpxA and SpxB of S. mutans. RNA was extracted from four replicate samples of each strain of interest (spxA mutant, spxB mutant, spxAB double-mutant, UA159 wild type) and labeled with Cy3. For each replicate, labeled RNA was hybridized...
ORGANISM(S): Streptococcus mutans 
2010-05-16 | E-GEOD-19656 | biostudies-arrayexpress
ProteomicsBiophysical, proteomic, and lipidomic characterization of Streptococcus mutans extracellular membrane vesicles from wild-type, ΔsrtA, and Δsfp strains provides novel information regarding vesiculogenesis and its function
Extracellular membrane vesicles (EMVs) are produced by many Gram-positive organisms, but information regarding vesiculogenesis is largely unknown. In this study, we isolated and characterized EMVs derived from the oral pathogen Streptococcus mutans and two deletion mutants, ΔsrtA and Δsfp. ΔsrtA E...
ORGANISM(S): Streptococcus mutans serotype C 
2020-11-17 | PXD019825 | Pride
Vesicles Lipidome Proteome Streptococcus mutans Membrane 
TranscriptomicsSubpopulation-specific transcriptome analysis of cytometrically sorted Streptococcus mutans cells: Analysis of CSP-mediated intrapopulation diversity
Transcriptional profiling of the competence-stimulating peptide (CSP) response in Streptococcus mutans of FACS-separated subpopulations and mixed cells of a clonal culture. CSP-mediated competence development in S. mutans is a transient and biphasic process since only a subpopulation induces expres...
ORGANISM(S): Streptococcus mutans 
2011-02-01 | E-GEOD-25284 | biostudies-arrayexpress
ProteomicsImmunorecognition of Streptococcus mutans secreted proteins protects against caries by limiting tooth adhesion
Childhood caries is an extremely common childhood chronic disease, affecting 60–90% of children in industrialized countries. It results in lesions in both the primary and permanent dentitions, hospitalizations and emergency room visits, high treatment costs, loss of school days, diminished ability t...
ORGANISM(S): Streptococcus mutans UA159 
2023-06-26 | PXD043103 | Pride
Caries  iga  mass-spectrometry  immunorecognition 
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