Sort   by:  
 Page size 
TranscriptomicsTranscriptional profiling of the developmental gene whiA deletion mutant of Streptomyces venezuelae ATCC 10712 at 7 time points from 8 to 20 hours of growth.
WhiA is an unusual transcriptional regulator found in Streptomyces species related to eukaryotic homing endonucleases. It plays a central role in sporulation in these bacteria. The aim of this transcription profiling experiment was to measure genome wide transcript levels in the wild type and the wh...
ORGANISM(S): Streptomyces venezuelae 
2020-12-11 | E-MTAB-9728 | biostudies-arrayexpress
GenomicsChIP-Seq of the Streptomyces venezuelae regulator BldD and its D116A mutant.
The dimerization and binding of DNA by BldD is affected by its interaction with cyclic di-GMP. The D116A mutant of BldD is partially impaired in its biding of cyclic di-GMP. ChIP-Seq was carried out to determine the difference in the degree of DNA binding by the wild type and D116A mutated BldD in S...
ORGANISM(S): Streptomyces venezuelae 
2017-11-01 | E-MTAB-5328 | biostudies-arrayexpress
GenomicsGenes required for aerial growth, cell division, and chromosome segregation are targets of WhiA before sporulation in Streptomyces venezuelae.
WhiA is a highly unusual transcriptional regulator related to a family of eukaryotic homing endonucleases. WhiA is required for sporulation in the filamentous bacterium Streptomyces, but WhiA homologues of unknown function are also found throughout the Gram-positive bacteria. To better understand th...
ORGANISM(S): Streptomyces venezuelae 
2016-05-20 | E-MTAB-4673 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of Streptomyces venezuelae wild type and bldN mutant strains
Transcription profiling by array of Streptomyces venezuelae wild type and bldN mutant strains during a time course from 8 to 20 hours, sampling at 2 hour intervals.
ORGANISM(S): Streptomyces venezuelae 
2012-05-15 | E-MEXP-3612 | biostudies-arrayexpress
ProteomicsIdentification of a regulatory cascade that activates chloramphenicol biosynthesis in Streptomyces venezuelae
Specialised metabolites made by the genus Streptomyces form the basis of 55% of clinically used antibiotics as well as cancer therapeutics, immunosuppressants and other anti-infectives. Streptomyces venezuelae is a model for the genus because it is fast-growing, sporulates in liquid culture within 2...
ORGANISM(S): Streptomyces venezuelae 
2026-05-21 | PXD064843 | Pride
Streptomyces Venezuelae Orra Wbla 
TranscriptomicsRNA-Seq of Streptomyces venezuelae grown overnight (14 hrs) with Mitomycin-C against untreated controls.
Mitomycin C is a DNA crosslinking agent. This experiment was carried out to determine the effect of Mitomycin C on genome wide transcription in Streptomyces venezuelae NRRL B65442.
ORGANISM(S): Streptomyces venezuelae 
2022-07-06 | E-MTAB-11556 | biostudies-arrayexpress
TranscriptomicsDifferential gene expression analysis by RNA-Seq for the bldC deletion strain and the wild type of Streptomyces venezuelae strain NRRL B-65442 after 10 and 14 hours of culture
The BldC gene is required for the formation of aerial hyphae in Streptomyces venezuelae. It is a 68 amino acid DNA-binding protein related to the MerR family of transcription factors. BldC deletion strains are bald because they initiate sporulation prematurely, omitting the formation of aerial hypha...
ORGANISM(S): Streptomyces venezuelae 
2019-01-14 | E-MTAB-7457 | biostudies-arrayexpress
TranscriptomicsRNA-Seq of Streptomyces venezuelae to compare global gene expression between the wild-type and BldB deletion strains after 10, 14 and 22 hours of growth.
BldB is a regulatory protein in Streptomyces and most species have a number of paralogs in their genomes. Deletion of BldB leads to a developmental deficiency and the colonies fail to produce aerial mycelium. In this experiment global gene expression was compared between the WT and BldB deletion str...
ORGANISM(S): Streptomyces venezuelae 
2023-04-14 | E-MTAB-12832 | biostudies-arrayexpress
TranscriptomicsChIP-Seq to determine the binding sites of the transcription factor WhiB in the genome of Streptomyces venezuelae
WhiB is the founding member of a family of proteins (the WhiB-like [Wbl] family) that carry a [4Fe-4S] iron-sulfur cluster. It is essential for the process of developmentally controlled cell division leading to sporulation in Streptomyces species. This ChIP-Sea was carried out to determine unambiguo...
ORGANISM(S): Streptomyces venezuelae 
2021-06-25 | E-MTAB-10648 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of the developmental gene whiB deletion mutant of Streptomyces venezuelae ATCC 10712 at 7 time points from 8 to 20 hours of growth
WhiB is the founding member of a family of proteins (the WhiB-like [Wbl] family) that carry a [4Fe-4S] iron-sulfur cluster and play key roles in diverse aspects of the biology of actinomycetes, including pathogenesis, antibiotic resistance, and the control of development. In Streptomyces, WhiB is es...
ORGANISM(S): Streptomyces venezuelae 
2021-06-30 | E-MTAB-10631 | biostudies-arrayexpress
Sort   by:  
 Page size