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TranscriptomicsThe Drosophila immune response towards entomopathogenic nematodes and their associated bacteria.
Entomopathogenic nematodes (EPNs) of the genera Heterorhabditis are obligate and lethal insect parasites. In recent years they have been used increasingly as biological control agents. These EPNs are symbiotically associated with bacteria of the genera Photorhabdus. The bacterial symbionts are essen...
ORGANISM(S): Drosophila melanogaster 
2014-03-07 | E-MTAB-1542 | biostudies-arrayexpress
TranscriptomicsPleiotropic effects of metformin on inflammation, oxidative and dicarbonyl stress in transgenic spontaneously hypertensive rats expressing human C-reactive protein.
Inflammation, oxidative and dicarbonyl stress play important roles in the pathophysiology of type 2 diabetes. Metformin is the first-line drug of choice for the treatment of type 2 diabetes because it effectively suppresses gluconeogenesis in the liver, however, its “pleiotropic“ effects remain cont...
ORGANISM(S): Rattus norvegicus 
2016-07-03 | E-MTAB-3791 | biostudies-arrayexpress
TranscriptomicsHow basic nuclear processes are affected by selected HAT and HDAC inhibitors - Signalling pathways affected by HATs/HDACs inhibitor
Balance between histone acetylation and deacetylation is fundamental for proper gene function, thus knowledge of how to modulate these epigenetic processes is important for understanding of nuclear events, including replication, transcription, splicing and DNA repair. Here, we have studied an effect...
ORGANISM(S): Homo sapiens 
2014-01-20 | E-MTAB-1481 | biostudies-arrayexpress
TranscriptomicsEffect of simvastatin on pancreatic cancer cells
The aim of our study was to assess the impact of simvastatin on the amount of cytosolic lipid droplets (LDs), which are implicated in many biological processes including proliferation, inflammation, carcinogenesis, apoptosis, necrosis or growth arrest. Human pancreatic cancer cells MiaPaCa-2 were t...
ORGANISM(S): Homo sapiens 
2013-11-21 | E-MTAB-1501 | biostudies-arrayexpress
TranscriptomicsEctopic activation of Wnt/beta-catenin signaling in lens fiber cells results in cataract formation.
Transgenic mouse line called alphaA-CLEF in which transactivation domain of beta-catenin is fused to the amino terminus of DNA-binding protein LEF and the expression of transgenic protein is controlled by alphaA-crystallin promoter (-342/+49) was used to mimic the activation of canonical Wnt/beta-c...
ORGANISM(S): Mus musculus 
2014-02-11 | E-MTAB-1691 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of cancer associated fibroblasts from pancreatic ductal adenocarcinoma in comparison to normal dermal fibroblasts
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive tumor type with extremely high mortality (up to 92%) during 5 years after diagnosis. Here, cancer associated fibroblasts (CAF) from PDAC were compared to CAF from melanoma metastases (MELF) and to normal dermal fibroblasts (DF). The analysis w...
ORGANISM(S): Homo sapiens 
2021-11-01 | E-MTAB-8764 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of irradiated non-adherent anoikis-resistant DU145 and MCF-7 cells and 5-azacytidine-treated non-adherent anoikis-resistant HeLa cells in contrast to control (non-irradiated, non-treated) cells.
Radiation and chemotherapy represent standard-of-care cancer treatments, however most treated patients eventually experience tumor recurrence, treatment failure and metastatic dissemination with fatal consequences. To elucidate molecular mechanisms of resistance to radio- and chemo-therapy, we expos...
ORGANISM(S): Homo sapiens 
2018-07-01 | E-MTAB-6062 | biostudies-arrayexpress
TranscriptomicsDipeptidyl peptidase-IV is associated with decreased glioma growth
Effect of expression of dipeptidyl peptidase-IV (DPP-IV) in U373 cell line on uncontrolled cell proliferation and aberrant interactions with the brain extracellular matrix.
ORGANISM(S): Homo sapiens 
2011-12-31 | E-MTAB-583 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human neural crest-originated stem cells, BLM melanoma cell line and neonatal highly pigmented melanocytes to study their production of extracellular factors.
Analysis of microarrays with transcriptome of human neural crest-originated stem cells (NCSC), highly metastatic BLM melanoma cell line and neonatal highly pigmented melanocytes (HPM) at whole genome scale demonstrated distinct differences among tested cell types.
ORGANISM(S): Homo sapiens 
2015-12-09 | E-MTAB-2401 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human fibroblasts from the stroma of squamous cell carcinoma and normal dermal fibroblasts
Head and neck squamous cancer stromal fibroblasts produce growth factors influencing phenotype of normal human keratinocytes. Epithelial-mesenchymal interaction between stromal fibroblasts and cancer cells influences the functional properties of tumor epithelium including the tumor progression and s...
ORGANISM(S): Homo sapiens 
2009-12-31 | E-MTAB-97 | biostudies-arrayexpress
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