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TranscriptomicsEctopic activation of Wnt/beta-catenin signaling in lens fiber cells results in cataract formation.
Transgenic mouse line called alphaA-CLEF in which transactivation domain of beta-catenin is fused to the amino terminus of DNA-binding protein LEF and the expression of transgenic protein is controlled by alphaA-crystallin promoter (-342/+49) was used to mimic the activation of canonical Wnt/beta-c...
ORGANISM(S): Mus musculus 
2014-02-11 | E-MTAB-1691 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human neural crest-originated stem cells, BLM melanoma cell line and neonatal highly pigmented melanocytes to study their production of extracellular factors.
Analysis of microarrays with transcriptome of human neural crest-originated stem cells (NCSC), highly metastatic BLM melanoma cell line and neonatal highly pigmented melanocytes (HPM) at whole genome scale demonstrated distinct differences among tested cell types.
ORGANISM(S): Homo sapiens 
2015-12-09 | E-MTAB-2401 | biostudies-arrayexpress
TranscriptomicsMicroenvironment-driven resistance to B-Raf inhibition in a melanoma patient is accompanied by broad changes of gene methylation and expression in distal fibroblasts. Genome methylation study.
In this study, we compared gene expression and genome methylation of diverse fibroblast populations from a patient suffering from acrolentiginous melanoma (Breslow 4.0 mm, Clark IV, B-Raf V600E mutated). Stromal cells from the metastasis, i.e., melanoma associated fibroblasts (MAF), were positive fo...
ORGANISM(S): Homo sapiens 
2018-12-30 | E-MTAB-4965 | biostudies-arrayexpress
TranscriptomicsMicroenvironment-driven resistance to B-Raf inhibition in a melanoma patient is accompanied by broad changes of gene methylation and expression in distal fibroblasts. Transcriptomic study.
In this study, we compared gene expression and genome methylation of diverse fibroblast populations from a patient suffering from acrolentiginous melanoma (Breslow 4.0 mm, Clark IV, B-Raf V600E mutated). Stromal cells from the metastasis, i.e., melanoma associated fibroblasts (MAF), were positive fo...
ORGANISM(S): Homo sapiens 
2018-12-31 | E-MTAB-4964 | biostudies-arrayexpress
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