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TranscriptomicsIdentification of Lgr5-independent spheroid-generating progenitors of the mouse fetal intestinal epithelium
Immortal spheroids were generated from fetal mouse intestine using the culture system developed to culture organoids from adult intestinal epithelium. Spheroids are made of a monostratified polarized epithelium displaying a poorly differentiated intestinal phenotype. The proportion of spheroids gene...
ORGANISM(S): Mus musculus 
2014-01-21 | E-GEOD-49803 | biostudies-arrayexpress
TranscriptomicsLgr4 is required for Paneth cell differentiation and maintenance of intestinal stem cells
Gene inactivation of the orphan G protein-coupled receptor Lgr4, a paralog of the epithelial stem cell marker Lgr5, results in 50% decrease of epithelial cell proliferation and 80% reduction in terminal differentiation of Paneth cells in postnatal mouse intestinal crypts. When cultured ex vivo, Lgr4...
ORGANISM(S): Mus musculus 
2012-03-10 | E-GEOD-27904 | biostudies-arrayexpress
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