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MetabolomicsMesenchymal stromal cells secretome restores bioenergetic and redox homeostasis in human proximal tubule cells after ischemic injury

BACKGROUND: Ischemia/reperfusion injury (IRI) is the leading cause of acute kidney injury (AKI). The current standard of care focuses on supporting kidney function, stating the need for more efficient and targeted therapies to enhance repair. Mesenchymal Stromal Cells (MSCs) and ...

2023-10-16 | MTBLS6279 | MetaboLights
MetabolomicsCancer-cell-secreted exosomal miR-105 promotes tumour growth through the Myc-dependent metabolic reprogramming of stromal cells
Cancer and other cells residing in the same niche engage various modes of interactions to synchronize and to buffer the negative effects of environmental changes. Extracellular miRNAs have been recently implicated in the intercellular crosstalk. Here we show a mechanistic model involving breast-canc...
2018-07-10 | MTBLS626 | MetaboLights
MetabolomicsMesenchymal stromal cell (MSC) Metabolite MS study
Not available
ORGANISM(S): Homo sapiens 
ST002469 | MetabolomicsWorkbench
MetabolomicsMulti-omic Attributes and Unbiased Computational Modeling for the Prediction of Immunomodulatory Potency of Mesenchymal Stromal Cells
Not available
ORGANISM(S): Homo sapiens 
ST002052 | MetabolomicsWorkbench
TranscriptomicsGene expression profiling of Resto6 human stromal cells
Resto6 stromal cells support the long-term survival of human plasma cells differentiated in vitro. Whole genome gene expression microarrays made it possible to pick up genes whose products could be involved in a biological pathway inducing long-term survival of plasma cells.
ORGANISM(S): Homo sapiens 
2013-12-11 | E-MTAB-2118 | biostudies-arrayexpress
ProteomicsDeep quantitative proteomics underlies extensive metabolic reprogramming and cancer-like changes of ectopic endometriotic stromal cells
Endometriosis is a prevalent health condition in women of reproductive age characterized by ectopic growth of endometrial tissue in the extrauterine environment. Thorough understanding of the molecular mechanisms underlying the disease are still lacking and incomplete. We dissect eutopic and ectopic...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-10-22 | MSV000080276 | MassIVE
TranscriptomicsTranscription profiling of human primary prostate epithelial and stromal cells exposed to 4-methylsulphinylbutyl and 3-methylsulphinypropyl isothiocyanates
BACKGROUND: Broccoli consumption has been associated with a reduction in risk of prostate cancer. Isothiocyanates (ITC) derived from glucosinolates that accumulate in broccoli are potential dietary compounds that may mediate these health effects. Sulforaphane (SF, 4-methylsulphinylbutyl ITC) accumul...
ORGANISM(S): Homo sapiens 
2009-06-05 | E-MEXP-2034 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse embryo-derived stromal cell lines
Hematopoiesis occurs in a microenviroenment in which stromal cells are prominent. Stromal cells have been shown to maintain stem cell behaviour of hematopoietic stem cells. We derived several different stromal cell lines from midgestation embryos which will, or will not maintain hemetopoietic stem c...
ORGANISM(S): Mus musculus 
2008-10-20 | E-GEOD-11589 | biostudies-arrayexpress
ProteomicsProteomic dataset of exosomes derived from fetal mesenchymal stromal cells
The raw files of the proteomics dataset are N=18 and a brief description of the files is shown below: AF1 raw: exosomes derived from Amniotic Fluid-Mesenchymal Stromal cells 1 AF2.raw: exosomes derived from Amniotic Fluid-Mesenchymal Stromal cells 2 AFA1.raw: exosomes derived from Amniotic Fl...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000092848 | MassIVE
TranscriptomicsUterine stromal cell_cultured with uNK conditioned Medium
The endometrium contains a distinct population of immune cells consisting of 70% natural killer (NK) cells that undergo cyclic changes during the menstrual cycle. However, how these uterine NK (uNK) cells interact with uterine stromal cells (SC) remains unclear. We therefore investigated the paracri...
ORGANISM(S): Homo sapiens 
2010-06-24 | E-GEOD-9718 | biostudies-arrayexpress
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