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GenomicsEssential role of microphthalmia transcription factor for DNA replication, mitosis and genomic stability in melanoma
Malignant melanoma is an aggressive cancer known for its notorious resistance to most current therapies. The basic helix-loop-helix microphthalmia transcription factor (MITF) is the master regulator determining the identity and properties of the melanocyte lineage, and is regarded as a lineage-speci...
ORGANISM(S): Homo sapiens 
2014-12-13 | E-GEOD-64137 | biostudies-arrayexpress
UnknownLysine Methyltransferase NSD1 and Cancers: Any Role in Melanoma?
Not available
S-EPMC9563040 | biostudies-literature
UnknownSETDB1 is critically required for uveal melanoma growth and represents a promising therapeutic target.
Not available
S-EPMC12552495 | biostudies-literature
UnknownTuning Transcription Factor Availability through Acetylation-Mediated Genomic Redistribution.
Not available
S-EPMC7427332 | biostudies-literature
TranscriptomicsIGR_MITF_STUDY_BBRB
A recent study of the characteristics of coexisting melanoma and renal cell carcinoma RCC in the same patients supports a genetic predisposition underlying the association between these two cancers. The microphthalmia associated transcription factor (MITF) was proposed to act as a melanoma oncogene;...
ORGANISM(S): Homo sapiens 
2011-09-03 | E-TABM-1198 | biostudies-arrayexpress
GenomicsHistone variant H2A.Z.2 mediates proliferation and drug sensitivity of malignant melanoma [native ChIP-seq]
Here we report a novel role for H2A.Z.2 (H2AFV) as a mediator of cell proliferation and sensitivity to targeted therapies in malignant melanoma. While both H2A.Z.1 and H2A.Z.2 are highly expressed in metastatic melanoma and correlate with decreased patient survival, only H2A.Z.2 deficiency results i...
ORGANISM(S): Homo sapiens 
2015-07-01 | E-GEOD-68222 | biostudies-arrayexpress
GenomicsMELARISK_SNP_MITF_geno
Genotypes at MITF E318K variant
EGAD00000000122 | EGA
GenomicsMELARISK_MITF_geno
Genotypes at MITF E318K variant
EGAD00000000121 | EGA
GenomicsA MITF germline mutation predisposes to melanoma and renal cell carcinoma
Study EGAS00000000048
EGAS00000000048 | EGA
GenomicsMELARISK Data Access Committee
Access to data generated by the MELARISK is available by emailing application to the data access committee and will be granted to qualified investigators for appropriate use.
EGAC00000000016 | EGA
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