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MetabolomicsMicrobial community-scale metabolic modelling predicts personalized short-chain fatty acid production profiles in the human gut
Microbially derived short-chain fatty acids (SCFAs) in the human gut are tightly coupled to host metabolism, immune regulation and integrity of the intestinal epithelium. However, the production of SCFAs can vary widely between individuals consuming the same diet, with lower levels often associated ...
2026-05-26 | MTBLS2308 | MetaboLights
MetabolomicsGenome-scale metabolic modelling of responses to polymyxins in Pseudomonas aeruginosa
Background: Pseudomonas aeruginosa often causes multidrug-resistant infections in immunocompromised patients and polymyxins are often used as the last-line therapy. Alarmingly, resistance to polymyxins has been increasingly reported worldwide recently. To rescue this last-resort class of antibiotics...
2018-02-28 | MTBLS630 | MetaboLights
TranscriptomicsDistinct structural transitions of chromatin topological domains coordinate hormone-induced gene regulation
The three-dimensional (3D) organization of the genome within the cell nucleus contributes to cell-specific gene expression in different cell types1. High-throughput 3CM-bM-^@M-^Sderived methods have revealed that the genome is segmented into contiguous topologically associating domains (TADs), which...
ORGANISM(S): Homo sapiens 
2014-10-06 | E-GEOD-53463 | biostudies-arrayexpress
UnknownModelling covalent linkages in CCP4.
Not available
S-EPMC8171069 | biostudies-literature
UnknownStructural Thermokinetic Modelling.
Not available
S-EPMC9144996 | biostudies-literature
TranscriptomicsSingle cell Hi-C reveals cell-to-cell variability in chromosome structure
Large-scale chromosome structure and spatial nuclear arrangement have been linked to control of gene expression and DNA replication and repair. Genomic techniques based on chromosome conformation capture assess contacts for millions of loci simultaneously, but do so by averaging chromosome conformat...
ORGANISM(S): Mus musculus 
2013-09-26 | E-GEOD-48262 | biostudies-arrayexpress
UnknownMultivariate dynamical modelling of structural change during development.
Not available
S-EPMC5315058 | biostudies-literature
UnknownTCRpMHCmodels: Structural modelling of TCR-pMHC class I complexes.
Not available
S-EPMC6787230 | biostudies-literature
ProteomicsIn Situ Structural Restraints from Crosslinking Mass Spectrometry in Human Mitochondria
The field of structural biology is increasingly focusing on studying proteins in situ, i.e. in a larger biological context. Crosslinking mass spectrometry is contributing to this effort, typically through the use of MS-cleavable crosslinkers. Here, we apply the popular non-cleavable crosslinker disu...
ORGANISM(S): Homo sapiens (Human) 
2019-12-03 | PXD014675 | Pride
Crosslinking mass spectrometry Human mitochondria In situ large-scale structural biology Non-cleavable dss crosslinker Comparative modelling 
UnknownHuman brain structural connectivity matrices-ready for modelling.
Not available
S-EPMC9363436 | biostudies-literature
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