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TranscriptomicsPOU2AF1 Functions in the Human Airway Epithelium to Regulate Expression of Host Defense Genes [array]
In the process of seeking novel lung host defense regulators by analyzing genome-wide RNA sequence data from normal human airway epithelium, we detected expression of POU2AF1, a known transcription co-factor previously thought to be expressed only in lymphocytes. Lymphocyte contamination of human ai...
ORGANISM(S): Homo sapiens 
2016-03-02 | E-GEOD-77658 | biostudies-arrayexpress
TranscriptomicsPOU2AF1 Functions in the Human Airway Epithelium to Regulate Expression of Host Defense Genes
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2016-03-02 | E-GEOD-77659 | biostudies-arrayexpress
TranscriptomicsSmoking-induced Wnt pathway downregulation
The Wnt pathway plays a central role in controlling differentiation of epithelial tissues; when Wnt is on, differentiation is suppressed, but when Wnt is off, differentiation is allowed to proceed. Based on this concept, we hypothesized that expression of key genes in the Wnt pathway are suppressed ...
ORGANISM(S): Homo sapiens 
2011-04-20 | E-GEOD-19407 | biostudies-arrayexpress
TranscriptomicseQTL analysis of many thousands of expressed genes while simultaneously controlling for hidden factors
Motivation: Identification of eQTL, the genetic loci that contribute to heritable variation in gene expression, can be obstructed by factors that produce variation in expression profiles if these factors are unmeasured or hidden from direct analysis. Methods: We have developed a method for Hidden Ex...
ORGANISM(S): Homo sapiens 
2014-01-07 | E-GEOD-40364 | biostudies-arrayexpress
TranscriptomicsEpithelial Expression of Toll-like Receptor 5 is Modulated in Healthy Smokers and Smokers with Chronic Obstructive Lung Disease
The toll-like receptors (TLRs) are important components of the respiratory epithelium host innate defense, enabling the airway surface to recognize and respond to a variety of insults in inhaled air. Based on the knowledge that smokers are more susceptible to pulmonary infection and the airway epith...
ORGANISM(S): Homo sapiens 
2012-10-03 | E-GEOD-30063 | biostudies-arrayexpress
TranscriptomicsSmoking-dependent Reprogramming of Alveolar Macrophage Polarization: Implication for Pathogenesis of COPD
Background: When exposed to specific stimuli, macrophages exhibit distinct activation programs, M1 and M2 polarization, that define macrophage function as inflammatory/immune effectors or anti-inflammatory/tissue remodeling cells, respectively. Due to their position on the lung epithelial surface, a...
ORGANISM(S): Homo sapiens 
2009-08-09 | E-GEOD-13896 | biostudies-arrayexpress
TranscriptomicsBiologic Phenotyping of the Human Small Airway Epithelial Response to Cigarette Smoking
The first changes associated with smoking are in the small airway epithelium (SAE). Given that smoking alters SAE gene expression, but only a fraction of smokers develop chronic obstructive pulmonary disease (COPD), we hypothesized that assessment of SAE genome-wide gene expression would permit biol...
ORGANISM(S): Homo sapiens 
2011-10-26 | E-GEOD-11784 | biostudies-arrayexpress
TranscriptomicsSmoking-induced Disarray of the Apical Junctional Complex Gene Expression Architecture in the Human Airway Epithelium
The apical junctional complex (AJC), composed of tight junctions and adherens junctions, is essential for maintaining epithelial barrier function. Since cigarette smoking and chronic obstructive pulmonary disease (COPD), the major smoking-induced disease, are both associated with increased lung epit...
ORGANISM(S): Homo sapiens 
2011-06-27 | E-GEOD-20257 | biostudies-arrayexpress
TranscriptomicsRNA-Seq Quantification of the Transcriptome of Genes Expressed in the Small Airway Epithelium of Nonsmokers and Smokers
The small airway epithelium (SAE) the pseudostratified epithelium that covers the majority of the human airway surface from the 6th generation to the alveoli, is the major site of lung disease caused by smoking, and the cell population that exhibits the earliest manifestations of smoking-induced dis...
ORGANISM(S): Homo sapiens 
2012-03-05 | E-GEOD-27681 | biostudies-arrayexpress
TranscriptomicsThreshold of Biologic Response of the Small Airway Epithelium to Low Levels of Tobacco Smoke
Background: Healthy individuals exposed to low levels of cigarette smoke have a decrement in lung function and higher risk for lung disease compared to unexposed individuals. We hypothesized that healthy individuals exposed to low levels of tobacco smoke must have biologic changes in the small airwa...
ORGANISM(S): Homo sapiens 
2011-02-02 | E-GEOD-19667 | biostudies-arrayexpress
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