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TranscriptomicsThe insulator protein SU(HW) modulates nuclear lamina interactions of the Drosophila genome: DamID
Specific interactions of the genome with the nuclear lamina (NL) are thought to assist chromosome folding inside the nucleus and to contribute to the regulation of gene expression. High-resolution mapping has recently identified hundreds of large, sharply defined lamina-associated domains (LADs) in ...
ORGANISM(S): Drosophila melanogaster 
2011-01-24 | E-GEOD-20311 | biostudies-arrayexpress
ProteomicsProteomes of chromatin fractions derived from SU-DHL-5 cells
SU-DHL-5 cells display limited expression of the SUMO isopeptidase SENP6. In this experiment, the chromatin associated fraction of SU-DHL-5 cells was analysed by mass spectrometry. SU-DHL-5 cells were either stably transfected with an empty vector or with a SENP6 expression construct. Changes in pro...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD027355 | Pride
Su-dhl-5 cells (b-cell lymphoma) 
TranscriptomicsIdentification of SUUR protein binding sites in Drosophila Kc cells using DamID
Salivary gland polytene chromosomes of Drosophila melanogaster have a reproducible set of intercalary heterochromatin sites, characterized by late DNA replication, underreplicated DNA, breaks and frequent ectopic contacts. The SuUR mutation has been shown to suppress underreplication, and wild-type ...
ORGANISM(S): Drosophila melanogaster 
2007-07-04 | E-MEXP-863 | biostudies-arrayexpress
Genomicshuman SU-DHL-5 and TMD-8 B-lymphome cell line subclones
Genetic heterogeneity though common in tumors has been rarely documented in cell lines. To examine how often B-lymphoma cell lines are comprised of subclones, we performed immunoglobulin (Ig) heavy chain hypermutation analysis. Revealing that subclones are not rare in B-cell lymphoma cell lines, 6/4...
ORGANISM(S): Homo sapiens 
2016-09-30 | E-MTAB-4956 | biostudies-arrayexpress
TranscriptomicsmicroRNA expression profile of activated primary B cells and miR181b overexpressing primary B cells
This SuperSeries is composed of the following subset Series: GSE12156: Murine spleen B cells miR181b vs control (G4122A) GSE12158: Murine spleen B cells miR181b vs control (G4122F) GSE12176: microRNA expression profile of activated versus non activated primary B cells Refer to individual Series
ORGANISM(S): Mus musculus 
2008-08-20 | E-GEOD-12186 | biostudies-arrayexpress
TranscriptomicsMurine spleen B cells miR181b vs control (G4122A)
Transcriptional profile of mouse primary spleen B cells overexpresing miR181b-GFP vectors compared to B cells overexpressing control-GFP vectors Keywords: Genetic modification Two-condition experiment: B-miR181b vs. B-control. Biological replicates: 1 control, 1 miR181b.
ORGANISM(S): Mus musculus 
2008-08-20 | E-GEOD-12156 | biostudies-arrayexpress
ProteomicsHSP90 promotes Burkitt lymphoma cell survival by maintaining tonic B cell receptor signaling
Burkitt’s lymphoma (BL) is an aggressive B-cell neoplasm that is currently treated by intensive chemotherapy in combination with anti-CD20 antibodies. Because of their toxicity, current treatment regimens are often not suitable for elderly patients or for patients in developing countries where BL is...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080781 | MassIVE
TranscriptomicsRole of miR-125b in B-cell acute lymphoblastic leukemia (B-ALL)
B-cell acute lymphoblastic leukemia (B-ALL) is often associated with chromosomal translocations leading to the deregulation of proto-oncogenes. MicroRNAs can also be affected by chromosomal alterations and thus contribute to carcinogenesis. The microRNA miR-125b-1 is over-expressed in B-ALL cases wi...
ORGANISM(S): Mus musculus 
2012-06-20 | E-GEOD-30647 | biostudies-arrayexpress
TranscriptomicsWT and Ikaros-deficient follicular B cells stimulated with anti-IgM
We have observed that follicular B cells from mice with a hypomorphic mutation (IkL/L) in the Ikzf1 gene (which encodes the Ikaros transcription factor) exhibit an increased proliferative response to anti-IgM stimulation (Kirstetter et al, Eur J Immunol, 32:720-30, 2002). We asked if Ikaros controls...
ORGANISM(S): Mus musculus 
2016-01-26 | E-GEOD-75712 | biostudies-arrayexpress
TranscriptomicsAffymetrix SNP array data for 4 MYC-negative B-cell lymphoma cases and 2 B-cell lymphoma cell lines (SU-DHL-5 and HT)
Affymetrix SNP arrays were performed according to the manufacturer's directions on DNA extracted from blood samples and cell lines Copy number analysis of Affymetrix SNP 6.0 arrays was performed for 4 MYC-negative B-cell lymphoma and 2 B-cell lymphoma cell lines
ORGANISM(S): Homo sapiens 
2014-01-10 | E-GEOD-47507 | biostudies-arrayexpress
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