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TranscriptomicsMicroarray for LPS-stimulated B cells compared to unstimulated B cells
Both multiple myeloma (MM) and systemic lupus erythematosus (SLE) are characterized with abnormal production of plasma cells. To explore the novel therapeutic target to plasma cells, we determined the gene expression profile in plasma cells by affymetrix microarrays. LPS could effectively in vitro i...
ORGANISM(S): Mus musculus 
2019-08-01 | E-MTAB-7109 | biostudies-arrayexpress
TranscriptomicsMicroarray for B cells of TACI-IgG-treated MRL/lpr mice compared to control mice
Both multiple myeloma (MM) and systemic lupus erythematosus (SLE) are characterized with abnormal production of plasma cells. In both diseases, the process of B cells differentiate into plasmablast/plasma cell is disordered. Despite the continuous research on the development of prognostic factors an...
ORGANISM(S): Mus musculus 
2019-07-30 | E-MTAB-7106 | biostudies-arrayexpress
TranscriptomicsMicroarray for activated B cells compared to naive B cells
B cells encounter antigen to activate and then differentiate into plasma cells. Both multiple myeloma (MM) and some autoimmune diseases such as multiple sclerosis (MS) and systemic lupus erythematosus (SLE) are characterized with abnormal production of plasma cells. In both diseases, the process of ...
ORGANISM(S): Mus musculus 
2019-08-01 | E-MTAB-7110 | biostudies-arrayexpress
TranscriptomicsAberrant DNA methylation in hepatitis B and C virus-related hepatocellular carcinoma
Chronic infections by hepatitis B virus (HBV) and hepatitis C virus (HCV) appear to be the most significant causes of hepatocellular carcinoma (HCC). Aberrant promoter methylation is known to be deeply involved in cancer, including HCC. In this study, we analyzed aberrant promoter methylation on gen...
ORGANISM(S): Homo sapiens 
2010-07-06 | E-GEOD-19665 | biostudies-arrayexpress
TranscriptomicsChromatin immunoprecipitation of wild type, SET2 deletion, Rco1 PHD domain deletion and Eaf3 chromodomain deletion yeast using anti-acetyl-histone H4
Nucleosomes must be deacetylated behind elongating RNA polymerase II to prevent cryptic initiation of transcription within the coding region. RNA polymerase II signals for deacetylation through methylation of histone H3 lysine 36 (H3K36) which provides the recruitment signal for the Rpd3S deacetylas...
ORGANISM(S): Saccharomyces cerevisiae 
2007-05-16 | E-TABM-260 | biostudies-arrayexpress
TranscriptomicsGenomic encoding of transcriptional burst kinetics
We used single-cell RNA-sequencing to generate allele-resolution expression levels in individual cells that we used for inference of transcriptional burst kinetics.
ORGANISM(S): Mus musculus 
2018-09-30 | E-MTAB-6362 | biostudies-arrayexpress
TranscriptomicsHepatic transcriptomic profiles of mice exposed to dechlorane plus by gavage
Five-week-old male mice (Mus musculus, ICR) were exposed to dechlorane plus for 10 days. A total of tweenty-four mice were randomly assigned to control and three DP-treated groups. Six mice were applied in every group. For control group, corn oil was given to mice by gavage daily. For three DP-treat...
ORGANISM(S): Mus musculus 
2012-09-05 | E-MEXP-3707 | biostudies-arrayexpress
TranscriptomicsThe Rpd3 Core Complex is a Chromatin Stabilization Module
The S. cerevisiae Rpd3 large (Rpd3L) and small (Rpd3S) histone deacetylase (HDAC) complexes are prototypes for understanding transcriptional repression in eukaryotes [1]. The current view is that they function by deacetylating chromatin, thereby limiting accessibility of transcriptional factors to t...
ORGANISM(S): Saccharomyces cerevisiae 
2012-01-01 | E-GEOD-33829 | biostudies-arrayexpress
TranscriptomicsA unique epigenetic signature is associated with active DNA replication loci in human embryonic stem cells
The cellular epigenetic landscape changes as pluripotent stem cells differentiate to somatic cells or when differentiated cells transform to a cancerous state. These epigenetic changes are commonly correlated with differences in gene expression. Whether active DNA replication is also associated with...
ORGANISM(S): Homo sapiens 
2013-11-05 | E-GEOD-43152 | biostudies-arrayexpress
TranscriptomicsMicrorna expression (Agilent McroRNA Array)
MicroRNA profiling of 3 Human NSCLC cell lines (PC9,PC9R,H1975)
ORGANISM(S): Homo sapiens 
2013-10-01 | E-MTAB-1327 | biostudies-arrayexpress
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