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TranscriptomicsSu(H) bound regions in Su(H) induced wing-disc hyperplasia
The outcome of Notch activation on proliferation depends on cellular context. In Drosophila wing discs Notch activation causes hyperplasia despite having localized inhibitory effects on proliferation. To understand the underlying mechanisms we have used genomic strategies to identify the Notch-Su(H)...
ORGANISM(S): Drosophila melanogaster 
2013-12-31 | E-GEOD-41425 | biostudies-arrayexpress
TranscriptomicsGenome-wide profiling of Su(H) in Drosophila melanogaster BG3 cell lines
The conserved Notch pathway functions in diverse developmental and disease-related processes, requiring mechanisms to ensure appropriate target-selection and gene activation in each context. To investigate, we partitioned Drosophila chromatin into different states, based on histone modifications, es...
ORGANISM(S): Drosophila melanogaster 
2015-07-01 | E-GEOD-66225 | biostudies-arrayexpress
TranscriptomicsGenome wide profiling of Su(H) [CSL] binding in Drosophila melanogaster larval CNSs where Notch is hyperactive in neuroblasts for 24 hours
The Notch pathway is a well conserved cell to cell communication mechanism that is normally involved in many developmental processes and when aberrantly activated it leads to diseases such as cancer. One such example is the neural stem cell tumours that arise from constitutive Notch activity in Dros...
ORGANISM(S): Drosophila melanogaster 
2015-12-15 | E-GEOD-68614 | biostudies-arrayexpress
GenomicsPolycomb repressive complex 2-dependent and -independent functions of Jarid2 in transcriptional regulation in Drosophila [ChIP-Seq]
Jarid2 was recently identified as an important component of the mammalian Polycomb Repressive Complex 2 (PRC2), where it has a major effect on PRC2 recruitment in mouse embryonic stem cells. Although Jarid2 is conserved in Drosophila, it has not previously been implicated in Polycomb (Pc) regulation...
ORGANISM(S): Drosophila melanogaster 
2012-02-23 | E-GEOD-33546 | biostudies-arrayexpress
TranscriptomicsChIP-chip time-course from DmD8 cells with Su(H) antibody after 0, 10, 20, 30 40, 60 and 100 minutes Notch activation
Cellular responses to signalling pathways are often highly dynamic, however most analyses of developmental signalling pathways focus on a single endpoint. We have analyzed the temporal changes in transcription following a short Notch activation treatment and related these to the recruitment of the N...
ORGANISM(S): Drosophila melanogaster 
2012-12-31 | E-GEOD-35719 | biostudies-arrayexpress
TranscriptomicsSu(H) bound regions in Nicd induced wing-disc hyperplasia
The outcome of Notch activation on proliferation depends on cellular context. In Drosophila wing discs Notch activation causes hyperplasia despite having localized inhibitory effects on proliferation. To understand the underlying mechanisms we have used genomic strategies to identify the Notch-Su(H)...
ORGANISM(S): Drosophila melanogaster 
2013-12-31 | E-GEOD-41426 | biostudies-arrayexpress
GenomicsTissue- and Stage-specific ChIP for H3K27ac, CTCF, Beaf and Su(Hw) in D. melanogaster embryos
This study contains a series of ChIP-seq experiments performed on nuclear material similar to what was used in Tissue- and Stage-specific Capture-C for selected TSS and CRM (BioStudies/ArrayExpress collection E-MTAB-9310). ChIP-seq with chromatin isolated from nuclei isolated from 2-3h whole embryos...
ORGANISM(S): Drosophila melanogaster 
2023-06-30 | E-MTAB-12639 | biostudies-arrayexpress
UnknownA Randomized Trial of Tai Chi on Preventing Hypertension and Hyperlipidemia in Middle-Aged and Elderly Patients.
Not available
S-EPMC8160700 | biostudies-literature
TranscriptomicsHP1a recruitment to promoters is independent of H3K9 methylation in Drosophila melanogaster
Heterochromatin protein 1 (HP1) proteins are important regulators of heterochromatin mediated gene silencing and chromosome structure and it is well known as the reader of the heterochromatin mark methylation of histone H3 lysine 9 (H3K9me). In Drosophila three different histone lysine methyl transf...
ORGANISM(S): Drosophila melanogaster 
2012-12-21 | E-GEOD-38366 | biostudies-arrayexpress
GenomicsmodENCODE_Lieb and White Lab: unltra-deep sequencing data of genomic DNA, chromatin input, and ChIP of Su(Hw) and H3K36me3 from S2 cells on Illumina Genome Analyzer.
This is a dataset generated by the modENCODE Project. It contains both the pair-end and single-end sequencing data of genomic DNA, chromatin input and the ChIP of the factors Su(Hw) and H3K36me3 from Drosophila S2 cells and it was generated on Illumina Genome Analyzer. The goal was to sequence ~120M...
ORGANISM(S): Drosophila melanogaster 
2011-03-04 | E-GEOD-27679 | biostudies-arrayexpress
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