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ProteomicsUnraveling the matrix: Proteomic profiling reveals stromal ECM dysregulation in severe early-onset fetal growth restriction
Severe, early-onset fetal growth restriction with absent or reversed end-diastolic umbilical artery velocities (FGRa/r) is marked by profound placental vascular insufficiency, yet the role of the villous stromal extracellular matrix (ECM) in this pathology remains poorly defined. Here, we applied an...
ORGANISM(S): Homo sapiens (Human) 
2025-12-08 | PXD070632 | Pride
Proteomics Fetal growth restriction Pregnancy Fibrosis Collagen Extracellular matrix Placenta 
ProteomicsA cullin-RING ubiquitin ligase promotes thermotolerance as part of the Intracellular Pathogen Response in C. elegans.
Intracellular pathogen infection leads to proteotoxic stress in host organisms. Previously we described a physiological program in the nematode C. elegans called the Intracellular Pathogen Response (IPR), which promotes resistance to proteotoxic stress and appears to be distinct from canonical prote...
ORGANISM(S): Caenorhabditis Elegans (ncbitaxon:6239) 
2020-02-07 | MSV000084936 | MassIVE
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