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TranscriptomicsRNA-Seq of eye tissue from a seasonally plastic temperate butterfly
Changes in sensory gene expression may underly seasonal changes in behavior. To accompany other research on seasonal changes in coloration and behavior in the seasonally plastic common buckeye butterfly Junonia coenia, we examined how gene expression in eyes differs between wild butterflies caught...
ORGANISM(S): Junonia coenia 
2025-10-24 | E-MTAB-15925 | biostudies-arrayexpress
TranscriptomicsSignatures of selection in the stickleback transcriptome.
Total RNA was extracted from liver tissues of lab-reared threespine stickleback. The dataset combines transcripts common to two experiments: first generation fish originating from the Baltic Sea near Helsinki (Finland) bred using a paternal half-sib design (E-MTAB-3098), and second generation fish...
ORGANISM(S): Gasterosteus aculeatus 
2014-12-03 | E-MTAB-3099 | biostudies-arrayexpress
GenomicsRUNX1 is a key target gene in t(4;11) leukemias and contributes to gene activation by interacting with the AF4-MLL complex
The Mixed Lineage Leukemia 1 protein (MLL1) is an important epigenetic regulator required for the maintenance of gene activation during development. MLL1 chromosome translocations produce novel fusion proteins that cause aggressive leukemias in humans. Individual MLL1 fusion proteins have distinct l...
ORGANISM(S): Homo sapiens 
2013-01-31 | E-GEOD-42075 | biostudies-arrayexpress
TranscriptomicsThe quantitative genetics of transcriptional variation in stickleback liver.
Total RNA was extracted from liver tissues of lab-reared threespine stickleback. First generation fish originating from the Baltic Sea near Helsinki (Finland) were bred using a paternal half-sib design. At 6 months individuals were randomly assigned to either a treatment or control group: the tem...
ORGANISM(S): Gasterosteus aculeatus 
2014-12-03 | E-MTAB-3098 | biostudies-arrayexpress
TranscriptomicsAssessing global transcriptomic changes in response to South African cassava mosaic virus [ZA-99] infection in susceptible Arabidopsis thaliana
In susceptible plant hosts, co-evolution has favoured viral strategies to evade host defenses and utilize resources to their own benefit. The degree of manipulation of host gene expression is dependent on host-virus specificity and certain abiotic factors. In order to gain insight into global transc...
ORGANISM(S): Arabidopsis thaliana 
2013-01-07 | E-GEOD-43282 | biostudies-arrayexpress
TranscriptomicsA Pathobiological Role of the Insulin Receptor in CLL.
Purpose: The chromosomal deletion 11q affects biology and clinical outcome in CLL but del11q-deregulated genes remain incompletely characterized. Results: We have identified differential expression of the insulin receptor (INSR) in CLL, including high-level INSR expression in the majority of CLL wi...
ORGANISM(S): Homo sapiens 
2011-05-05 | E-GEOD-26526 | biostudies-arrayexpress
ProteomicsAP-MS MudPIT run of Ino80 complex
File name explanation: Sc_Ino80_TAP_V2_P1_Ti_101: Sc = Saccharomyces cerevisiae (specie) Ino80 = bait protein TAP = tag V2 = lab instrument name(Velos_Elite2) P1 = biological replicate 1 Ti = LysC+Trypsin digestion 101 = MudPIT run 1 from 1st technical replicate
ORGANISM(S): Saccharomyces Cerevisiae (ncbitaxon:4932) 
2015-01-28 | MSV000079018 | MassIVE
ProteomicsAP-MS MudPIT run of Swr1 complex
File name explanation: Sc_Swr1_TAP_V2_P1_Ti_101: Sc = Saccharomyces cerevisiae (specie) Swr1 = bait protein TAP = tag V2 = lab instrument name(Velos_Elite2) P1 = biological replicate 1 Ti = LysC+Trypsin digestion 101 = MudPIT run 1 from 1st technical replicate
ORGANISM(S): Saccharomyces Cerevisiae (ncbitaxon:4932) 
2015-01-28 | MSV000079019 | MassIVE
TranscriptomicsInactivation of the exosome ribonuclease DIS3 triggers the pluripotency factor LIN28B, repressing let-7 miRNAs and unleashing MYC and RAS.
Somatic mutations affecting DIS3, the catalytic component of the RNA exosome, have been found in up to 18% of patients affected by the hematological cancer multiple myeloma. Here we show that DIS3 targets and degrades the pluripotency factor LIN28B. In cancer cells, DIS3 inactivation leads to enhanc...
ORGANISM(S): Homo sapiens 
2015-06-12 | E-GEOD-55246 | biostudies-arrayexpress
TranscriptomicsMacrophage-specific gene functions in Spi1-directed innate immunity
The Spi1/ Pu.1 transcription factor plays a crucial role in myeloid cell development across many species. Several Spi1 target genes have been identified so far, yet the Spi1-dependent gene group remains largely unknown. To identify novel genes downstream of Spi1 we employed a microarray strategy usi...
ORGANISM(S): Danio rerio 
2010-04-30 | E-GEOD-19206 | biostudies-arrayexpress
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