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TranscriptomicsThe role of the Ras- and cAMP-signaling pathways in stress response and sterol biosynthesis in Cryptococcus neoformans
The cAMP-pathway plays a central role in regulation of growth, differentiation, and virulence of human pathogenic fungi, including Cryptococcus neoformans. Three major upstream signaling regulators of the adenylyl cyclase (Cac1), Ras, Aca1 (Adenylyl cyclase-associated protein 1) and G-alpha subunit ...
ORGANISM(S): Cryptococcus neoformans var. grubii H99 
2010-05-22 | E-GEOD-17338 | biostudies-arrayexpress
TranscriptomicsComparative transcriptome analysis of the CO2 sensing pathway via differential expressions of carbonic anhydrase in Cryptococcus neoformans
Carbon dioxide (CO2) sensing, transport, and metabolism play a pivotal role in survival and proliferation of pathogenic microbes infecting human host from natural environments due to the drastic difference of CO2 levels. Carbonic anhydrases (CAs) are not only key CO2-metabolic enzymes catalyzing rev...
ORGANISM(S): Cryptococcus neoformans var. grubii H99 
2010-05-31 | E-GEOD-21192 | biostudies-arrayexpress
UnknownLarge language models for predicting one-year major adverse cardiovascular events in acute coronary syndrome.
Not available
S-EPMC12874424 | biostudies-literature
TranscriptomicsTranscription profiling of human lung carcinome calls treated WITH Farnesol reveals Farnesol-induced apoptosis IS coupled TO THE endoplasmic reticulum (ER) stress response
Farnesol (FOH) and other isoprenoid alcohols induce apoptosis in various carcinoma cells and inhibit tumorigenesis in several in vivo models. However, the mechanisms by which these isoprenoids mediate their effects are not yet fully understood. In this study, we show that FOH is effective inducer of...
ORGANISM(S): Mus musculus 
2008-04-07 | E-GEOD-7215 | biostudies-arrayexpress
TranscriptomicsThe bZIP transcription factor Atf1 governs the oxidative stress response and sexual differentiation of Cryptococcus neoformans downstream of the HOG pathway
The high osmolarity glycerol response (HOG) pathway plays a pivotal role in the stress response, virulence regulation, and differentiation of fungi, including Cryptococcus neoformans that causes fatal meningoencephalitis. Core signaling components of in the HOG pathway, including the Tco-Ypd1-Ssk1 p...
ORGANISM(S): Cryptococcus neoformans var. grubii 
2015-01-13 | E-GEOD-64871 | biostudies-arrayexpress
UnknownImplementation and Impact of the Pulmonary Specialist Health Coach Consultation Model to Improve Care for Patients with COPD.
Not available
S-EPMC12685618 | biostudies-literature
TranscriptomicsPleiotropic roles of Msi1-like protein, Msl1, in growth, differentiation, stress response, and virulence of Cryptococcus neoformans
WD40 motif-containing Msi1-like (MSIL) proteins play pleiotropic cellular functions as a negative regulator of the Ras/cAMP-pathways and a component of chromatin assembly factor-I (CAF-I), and yet have not been studied in fungal pathogens. Here we identified and characterized an MSIL protein, Msl1, ...
ORGANISM(S): Cryptococcus neoformans var. grubii H99 
2012-08-23 | E-GEOD-40303 | biostudies-arrayexpress
UnknownLay Health Coaching to Increase Appropriate Inhaler Use in COPD: A Randomized Controlled Trial.
Not available
S-EPMC7227462 | biostudies-literature
UnknownHealth coaching to improve self-management and quality of life for low income patients with chronic obstructive pulmonary disease (COPD): protocol for a randomized controlled trial.
Not available
S-EPMC5466738 | biostudies-literature
UnknownRandomized Controlled Trial of Health Coaching for Vulnerable Patients with Chronic Obstructive Pulmonary Disease.
Not available
S-EPMC6321989 | biostudies-literature
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