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TranscriptomicsTranscription profiling of Arabidopsis treated with Trichostatin A (TSA) to inhibit of histone deacetylase in Arabiodopsis thaliana
Histone acetylation is involved in the regulation of gene expression in plants and eukaryotes. Histone deacetylases (HDACs) are enzymes that catalyze the removal of acetyl groups from histones, which is associated with the repression of gene expression. To study the role of histone acetylation in ...
ORGANISM(S): Arabidopsis thaliana 
2008-06-12 | E-GEOD-3783 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Arabidopsis treated with Histone acetylation during seed germination (GEO Super Series)
This SuperSeries is composed of the following subset Series:; GSE3783: Trichostatin A (TSA) inhibition of histone deacetylase in Arabiodopsis thaliana; GSE3784: Seed germination in presence and absence of histone deaceatylase inhibitor, Trichostain A (TSA). Histone acetylation is involved in the reg...
ORGANISM(S): Arabidopsis thaliana 
2008-06-12 | E-GEOD-3799 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Arabidopsis seed germination in presence and absence of histone deaceatylase inhibitor, Trichostain A (TSA).
Histone acetylation is involved in the regulation of gene expression in plants and eukaryotes. Histone deacetylases (HDACs) are enzymes that catalyze the removal of acetyl groups from histones, which is associated with the repression of gene expression. To study the role of histone acetylation in ...
ORGANISM(S): Arabidopsis thaliana 
2008-06-12 | E-GEOD-3784 | biostudies-arrayexpress
MetabolomicsELAPOR1 induces the classical/progenitor subtype and contributes to reduced disease aggressiveness through metabolic reprogramming in pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) is a heterogeneous disease with distinct molecular subtypes described as classical/progenitor and basal-like/squamous PDAC. We hypothesized that integrative transcriptome and metabolome approaches can identify candidate genes whose inactivation contributes to ...
2024-04-02 | MTBLS9418 | MetaboLights
MetabolomicsMethod Comparison using DBS samples

Metabolomics serves as a critical pillar in clinical research, yet the lack of standardized protocols often limits the comparability of data across different platforms and institutions. The HUMAN (Harmonizing and Unifying Blood Metabolomics Network) has as one of its goals to to advance the field...

2026-05-19 | MTBLS14519 | MetaboLights
TranscriptomicsGene expression profiles of Hyalella azteca populations with different pyrethroid sensitivities
The goal of the study was to investigate gene expression differences in Hyalella azteca exposed to pyrethroid insecticides and compare a laboratory strain to a wild population believed to be resistant to the pesticides. H. azteca reared in the laboratory at the University of CA, Berkeley (UCB) were...
ORGANISM(S): Hyalella azteca 
2013-07-17 | E-GEOD-48943 | biostudies-arrayexpress
Proteomics- Identification of Gαi2-interacting proteins via affinity pull-down and quantitative mass-spectrometry analysis.
In studying patients with activating GNAI2 mutations, we observed T cell hyperresponsiveness that was independent of cAMP suppression. Therefore, we hypothesized that Gαi2 utilizes alternative signal transduction pathways which might be delineated by identifying its interacting proteins in T cells. ...
ORGANISM(S): Homo sapiens (Human) Escherichia coli 
2024-09-20 | PXD048980 | Pride
Gpcrs G-protein coupled receptors Gnai2 - gαi2 G-protein 
UnknownAutophagy facilitates glycolysis during Ras-mediated oncogenic transformation.
Not available
S-EPMC3020913 | biostudies-literature
TranscriptomicsPredominance of MAPK reactivation in early resistance to debrafenib/trametinib combination therapy of BRAF mutant metastatic melanoma.
One third of BRAF-mutant metastatic melanoma patients treated with combined BRAF and MEK inhibition progress within six months. Treatment options for these patients remain limited. Here we analyse twenty BRAFV600 mutant melanoma metastases derived from 10 patients treated with the combination of deb...
ORGANISM(S): Homo sapiens 
2014-12-03 | E-GEOD-61992 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse MyD88-deficient bone marrow-derived macrophages treated with Zymosan
Innate immune pattern recognition receptors play critical roles in pathogen detection and initiation of antimicrobial responses. We and others have previously demonstrated the importance of the beta-glucan receptor Dectin-1 in the recognition of pathogenic fungi by macrophages and dendritic cells, a...
ORGANISM(S): Mus musculus 
2008-06-14 | E-GEOD-6376 | biostudies-arrayexpress
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