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UnknownThe correlation between proprotein convertase subtilisin/kexin type 9 and adiponectin in the progression from prediabetes to type 2 diabetes mellitus.
Not available
S-EPMC11903854 | biostudies-literature
GenomicsDeregulation of the Ras-Erk Signaling Axis Modulates the Enhancer Landscape [ChIP-seq]
Unrestrained receptor tyrosine kinase (RTK) signaling and epigenetic deregulation are root causes of tumorigenesis. We establish linkage between these processes by demonstrating that aberrant RTK signaling unleashed by oncogenic HRasG12V or loss of negative feedback through Sprouty gene deletion rem...
ORGANISM(S): Mus musculus 
2015-08-22 | E-GEOD-64190 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Mia PaCa-2 cancer cells treated with a cell-permeable RAS inhibitor and its negative control
The action mechanism of a cell-permeable RAS inhibitor (Pen-cRaf-v1) and its binding-disrupting mutant (Pen-cRaf-v1-AA) was studied by transcription profiling of Mia PaCa-2 cancer cells treated with the inhibitors at the concentration of 10 microM for 3 hours.
ORGANISM(S): Homo sapiens 
2021-06-01 | E-MTAB-10403 | biostudies-arrayexpress
TranscriptomicsDeregulation of the Ras-Erk Signaling Axis Modulates the Enhancer Landscape [RNA-seq]
Unrestrained receptor tyrosine kinase (RTK) signaling and epigenetic deregulation are root causes of tumorigenesis. We establish linkage between these processes by demonstrating that aberrant RTK signaling unleashed by oncogenic HRasG12V or loss of negative feedback through Sprouty gene deletion rem...
ORGANISM(S): Mus musculus 
2015-08-22 | E-GEOD-63497 | biostudies-arrayexpress
TranscriptomicsRAS/MAPK activation drives resistance to Smo inhibition, metastasis and tumor evolution in Shh pathway-dependent tumors
Aberrant Shh signaling promotes tumor growth in diverse human cancers. The importance of Shh signaling is particularly evident in medulloblastoma and basal cell carcinoma (BCC), where inhibitors targeting the Shh pathway component Smoothened (Smo) show great therapeutic promise. However, the emergen...
ORGANISM(S): Mus musculus 
2015-07-22 | E-GEOD-69359 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human MCF10A cells reveal changes upon expression of activated versions of MEK1 and HRAS
MCF10A cells were then transfected with MEK1(S217S221), HRAS(G12V), and null control vectors; Cells were lysed 24 hours post-transfection with collection of total RNA and protein Experiment Overall Design: Overexpression of Oncogenic protein was confirmed via Western blot
ORGANISM(S): Homo sapiens 
2009-01-17 | E-GEOD-12764 | biostudies-arrayexpress
UnknownPyrroloquinoline quinone inhibits PCSK9-NLRP3 mediated pyroptosis of Leydig cells in obese mice.
Not available
S-EPMC10630350 | biostudies-literature
TranscriptomicsDeregulation of the Ras-Erk Signaling Axis Modulates the Enhancer Landscape
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2015-08-22 | E-GEOD-64195 | biostudies-arrayexpress
UnknownAssociation between serum PCSK9 and coronary heart disease in patients with type 2 diabetes mellitus.
Not available
S-EPMC10731704 | biostudies-literature
TranscriptomicsRNA-SEQ analysis of KMC murine pancreatic ductal adenocarcinoma (PDAC) cell line upon siRNA depletion of MYC, KRas or Miz1 (aka Zbtb17)
MYC is varyingly thought to either complement KRAS or to act as a downstream KRAS effector - here we compared the transcriptomic impact of MYC depletion with that of KRas depletion in a cell line derived from PDAC driven by lsl-KRas^G12D + Rosa26-lsl-MYC^DM. A second question addressed related to t...
ORGANISM(S): Mus musculus 
2020-03-16 | E-MTAB-8792 | biostudies-arrayexpress
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