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MetabolomicsUntargeted serum metabolomics of early-life antibiotic intervention, fecal microbiota transplantation restoration, and short-term high-fat diet effects in C57BL/6 mice
This study profiles the serum metabolome in C57BL/6 mice subjected to early-life antibiotic treatment (vancomycin and gentamicin, 2 weeks), followed by fecal microbiota transplantation and a short-term high-fat diet. Serum samples were collected longitudinally and analyzed by liquid chromatography-t...
2026-08-20 | MTBLS14801 | MetaboLights
TranscriptomicsMicroRNA-674-5p/5-LO axis is important in concanavalin A-induced acute mouse liver injury
Eight-week-old male pathogen-free BALB/c mice were used for the induction of concanavalin A (Con A)-induced hepatitis. Animals were acclimated for at least 6-7 days to a 12-hour light/dark cycle in a humidity- and temperature-controlled, specific-pathogen-free environment in autoclaved cages. Mice w...
ORGANISM(S): Mus musculus 
2016-06-27 | E-GEOD-76345 | biostudies-arrayexpress
GenomicsGenome-wide maps of CtBP binding profile in breast cancer cell line MCF-7
CtBP is a global co-repressor by serving as transcriptional factor in multiple pathways. CtBP functioned as transcriptional factor by recruiting other cofactors such as G9a, HDAC1 and PcG proteins. CtBP is found to be over enriched in several type of tumor samples. To dipict the role of CtBP in glob...
ORGANISM(S): Homo sapiens 
2013-03-20 | E-GEOD-36546 | biostudies-arrayexpress
TranscriptomicsExpression data from CtBP knockdown MCF-7 cells
CtBP is a global co-repressor by serving as transcriptional factor in multiple pathways. CtBP functioned as transcriptional factor by recruiting other cofactors such as G9a, HDAC1 and PcG proteins. CtBP is found to be over enriched in several type of tumor samples. To dipict the role of CtBP in glob...
ORGANISM(S): Homo sapiens 
2013-03-20 | E-GEOD-36529 | biostudies-arrayexpress
MetabolomicsRcrR: A Multifunctional Transcriptional Regulator Orchestrating the cariogenic virulence of Streptococcus mutans

We systematically investigated RcrR's contribution to cariogenic virulence using isogenic wild-type, DeltarcrR deletion mutant, and complemented strains. We assessed bacterial growth, biofilm architecture, acid tolerance, and H+-ATPase activity. To delineate the global regulatory network, we inte...

2026-08-06 | MTBLS15272 | MetaboLights
ProteomicsHuman DLBCL cell line proteome and ubiquitinome
The mass spectrometry-based quantitative proteome analysis was firstly performed to reveal the role of up-regulated CENPF in DLBCL cell line, then various proteins were found mainly enriched with various ubiquitin related kinases activity and ubiquitination process, then the ubiquitinome analysis wa...
ORGANISM(S): Homo Sapiens 
2022-11-18 | PXD038224 |
Proteomicsproteome and phosphoproteome profiling of nonsmall cell lung cancer cells treated by TRAIL
tumor necrosis factor-related apoptosis-inducing liagand is one of the promising cancer therapeutic, however, many tumors have developed different degrees of drug resistance during TRAIL treatment. the mechanism by which is unvlear, and here we reasoned that systematic proteomic and phosphoproteomic...
ORGANISM(S): Homo Sapiens 
2022-06-06 | PXD034338 |
ProteomicsDissection of Blood Ecosystem in SARS-CoV-2 Omicron Patients
Here, we systematically profiled clinical phenomes, transcriptomes, proteomes, metabolomes, and immune repertoire of blood cells or plasma in over 1000 specimens from SARS-CoV-2 Omicron patients across multiple disease phases.
ORGANISM(S): Homo Sapiens 
2024-08-02 | PXD045174 |
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