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MetabolomicsHyocholic acid species as novel biomarkers for metabolic disorders
Hyocholic acid (HCA) is a major bile acid (BA) species in the BA pool of pigs, a species known for its exceptional resistance to spontaneous development of diabetic phenotypes. HCA and its derivatives are also present in human blood and urine. We investigate whether human HCA profiles can predict th...
2021-10-06 | MTBLS2343 | MetaboLights
TranscriptomicsThe gene encoding the hematopoietic stem cell regulator CCN3 (NOV) is under direct cytokine control through the transcription factors STAT5a/b.
Cytokines control the biology of hematopoietic stem and progenitor cells in part through the transcription factors STAT5a/b. CCN3/NOV has been reported as a positive regulator of hematopoietic stem and progenitor cells. We report microarray analyses of Lineage- Sca-1+ c-Kit+ (KSL) cells in the pre...
ORGANISM(S): Mus musculus 
2010-08-25 | E-GEOD-20684 | biostudies-arrayexpress
TranscriptomicsDevelopment of mammary luminal progenitor cells is controlled by the transcription factor STAT5A
Mammary alveologenesis is abrogated in the absence of the transcription factors STAT5A/5B that mediate cytokine signaling. To reveal the underlying causes for this developmental block we studied mammary stem and progenitor cells. While loss of STAT5A/5B did not affect the stem cell population and ...
ORGANISM(S): Mus musculus 
2009-10-21 | E-GEOD-17723 | biostudies-arrayexpress
TranscriptomicsHeme utilization in the Caenorhabditis elegans hypodermal cells is facilitated by HRG-2
The roundworm Caenorhabditis elegans is a heme auxotroph that requires the coordinated actions of HRG-1 heme permeases to transport environmental heme into the intestine and HRG-3, a secreted protein, to deliver intestinal heme to other tissues including the embryo. Here we show that heme homeostas...
ORGANISM(S): Caenorhabditis elegans 
2013-01-01 | E-GEOD-34471 | biostudies-arrayexpress
Genomicsena-DATASET-GoT2D/T2D-GENES-08-07-2016-21:22:44:693-1130 - samples
The T2D-GENES/GoT2D 13K exome sequencing study includes ~13,000 samples, half T2D cases and half T2D controls, from five ancestries (~5K Europeans, ~2K each of African-American, East-Asian, South-Asian, and Hispanic). Samples underwent deep exome sequencing, with SNVs and INDEls called according to ...
EGAD00001002246 | EGA
TranscriptomicsRTN1 IS A NOVEL MEDIATOR FOR PROGRESSION OF KIDNEY DISEASE
Gene expression profiling of kidneys from the murine model of HIV-associated nephropathy (HIVAN) identified an association between the expression of an endoplasmic reticulum (ER)-associated protein reticulon-1, RTN1, and the severity of kidney disease. Of the three known RTN1 isoforms, only RTN1A pr...
ORGANISM(S): Mus musculus 
2015-05-20 | E-GEOD-69074 | biostudies-arrayexpress
TranscriptomicsIsraeli acute paralysis virus – what we have learned about the virus since mysterious disappearance of the US honey bees known as Colony Collapse Disorder (CCD) in 2006
There were important gaps in our knowledge of Israeli acute paralysis virus (IAPV), when IAPV was tightly linked to bee Colony Collapse Disorder (CCD), the mysterious disease that, starting in 2006-2007, has been wiping out honey bees in the US. To fill in these gaps we studied the molecular basis ...
ORGANISM(S): Apis mellifera 
2014-04-08 | E-GEOD-46278 | biostudies-arrayexpress
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