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TranscriptomicsAn Artificial miRNA Against HSPE Suppresses Melanoma Invasion Properties Correlating with a Down-regulation of Chemokines and MAPK Phosphorylation
Heparanase (HPSE) is an endo-beta-glucuronidase that can cleave heparan sulfate proteoglycans within extracellular matrix, basement membrane or on the cellular surface, closely linked with proliferation, migration, invasion and angiogenesis of tumor cells, and has become a hot treatment target in an...
ORGANISM(S): Homo sapiens 
2012-10-27 | E-MEXP-3443 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of pituitary glands from wild type and LSD1 knock-out mice
Precise control of transcriptional programs underlying metazoan development is modulated by enzymatically active co-regulatory complexes, coupled with epigenetic strategies, but how specific members of histone modification enzyme families such as histone methyltransferases and demethylases are utili...
ORGANISM(S): Mus musculus 
2007-02-13 | E-TABM-223 | biostudies-arrayexpress
TranscriptomicsExpression data of one-week-old rice seedlings exposed to Pi-deficient solution for 6, 24, 48, 72 hours
Expression profiles of one-week-old rice seedlings exposed to Pi-deficient solution for 6, 24, 48, 72 hours were monitored by microarray that contains approximately 60,000 rice clones (Affymetrix GeneChip). The probes were prepared from RNAs isolated from rice seedlings exposed to Pi-deficient solut...
ORGANISM(S): Oryza sativa Japonica Group 
2012-06-17 | E-GEOD-35984 | biostudies-arrayexpress
MetabolomicsMulti-kingdom gut microbiota dysbiosis is associated with the development of pulmonary arterial hypertension

Gut microbiota dysbiosis has been implicated in pulmonary arterial hypertension (PAH). However, most studies have focused on the bacterial community and the exact role and mechanisms of multi-kingdom gut microbiota, including bacteria, archaea and fungi in PAH remains largely unclear. Idiopathic ...

2025-05-12 | MTBLS10563 | MetaboLights
TranscriptomicsAberrantly expressed lncRNAs in Primary Varicose Great Saphenous Veins
LncRNAs are key regulatory molecules involved in a variety of biological process and human diseases. However, the pathological effects of lncRNAs on primary varicose great saphenous veins (GSVs) remain unclear. In this study, we aimed at identifying aberrantly expressed lncRNAs involved in the preva...
ORGANISM(S): Homo sapiens 
2013-10-01 | E-GEOD-51260 | biostudies-arrayexpress
ProteomicsIntegrative proteomic and phosphoproteomic analyses reveal complex mechanisms of reproductive diapause in Bombus terretris queens (phosphoproteome)
Reproductive diapause is the overwintering strategy for Bombus terrestris, which is an important pollinator for agricultural production. However, the precise mechanisms of the reproductive diapause in bumble bees remain largely unclear. Here, a combination analyses of proteomics and phosphoproteomic...
ORGANISM(S): Bombus Terrestris 
2022-05-28 | PXD034199 |
ProteomicsIntegrative proteomic and phosphoproteomic analyses reveal complex mechanisms of reproductive diapause in Bombus terretris queens (proteome)
Reproductive diapause is the overwintering strategy for Bombus terrestris, which is an important pollinator for agricultural production. However, the precise mechanisms of the reproductive diapause in bumble bees remain largely unclear. Here, a combination analyses of proteomics and phosphoproteomic...
ORGANISM(S): Bombus Terrestris 
2022-05-28 | PXD034198 |
ProteomicsTIGAR Regulates Intestinal Mucus Barrier Integrity by Inhibiting Lactylation of G6PD/6PGD in Ulcerative Colitis
Oxidative stress and metabolic dysregulation in goblet cells represent significant contributors to the pathogenesis of ulcerative colitis (UC). TIGAR (TP53-induced glycolysis and apoptosis regulator) plays a critical role as a metabolic regulatory enzyme by promoting NADPH synthesis, thereby counter...
ORGANISM(S): Homo Sapiens 
2025-10-09 | PXD069246 |
ProteomicsMulti-omics profiling reveals systemic rejuvenation of the aged kidney through senolytic therapy
Cellular senescence is a key driver of kidney aging, leading to functional decline and increased susceptibility to chronic kidney disease. While the senolytic combination of dasatinib and quercetin (D+Q) has shown promise in mitigating age-related pathologies, its long-term effects and underlying mu...
ORGANISM(S): Homo Sapiens 
2026-03-24 | PXD076057 |
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