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TranscriptomicsX-inactivation in hESCs
X chromosome inactivation (XCI) is a dosage compensation mechanism in female cells to regulate X-linked gene expression. We report here that subcultures from established lines of female hESCs displayed variations (0-100%) in the expression of XCI markers such as XIST RNA coating and enrichment of h...
ORGANISM(S): Homo sapiens 
2010-05-26 | E-GEOD-9637 | biostudies-arrayexpress
GenomicsDerivation of pre-X inactivation human embryonic stem cells under physiological oxygen concentrations
The presence of two active X chromosomes (XaXa) is a hallmark of the ground state of pluripotency specific to murine embryonic stem cells (ESCs). Human ESCs invariably exhibit signs of X chromosome inactivation (XCI) and are considered developmentally more advanced than their murine counterparts. W...
ORGANISM(S): Homo sapiens 
2010-05-28 | E-GEOD-21141 | biostudies-arrayexpress
TranscriptomicsAnalysis of Drosophila salivary glands and Kc cells with depleted levels of linker histone H1 (Illumina smRNA-Seq]
Salivary glands or larval ovaries were isolated from transgenic flies expressing RNAi targeting Nautilus (control) or linker histone H1 using a Tub-Gal4 driver. ~200 larvae were used to isolate salivary glands or ovaries, independently. Total RNA was isolated using Trizol reagent following manufact...
ORGANISM(S): Drosophila melanogaster 
2013-04-22 | E-GEOD-44399 | biostudies-arrayexpress
TranscriptomicsAnalysis of Drosophila salivary glands and Kc cells with depleted levels of linker histone H1 [Affymetrix Expression]
Indicated cells were subjected to RNAi against linker histone H1, Nautilus (control), or GFP (control). RNA was isolated and subjected to Affymetrix GeneChIP Drosophila Genome 2.0 arrays RNA was compared from cells treated with RNAi against control (Nautilus in the case of salivary glands or GFP in...
ORGANISM(S): Drosophila melanogaster 
2013-04-22 | E-GEOD-44398 | biostudies-arrayexpress
GenomicsHeterochromatin remodeling by CDK12 contributes to learning in Drosophila
We describe the epigenetic profiling of the H3K9me2 and HP1a in Drosophila third instar larvae before and after CDK12 depletion by RNA interference (RNAi). Here we show that CDK12 regulates heterochromatin dynamics in Drosophila chromosomes. Depletion of CDK12 induces the increased HP1a and H3K9me2 ...
ORGANISM(S): Drosophila melanogaster 
2015-11-02 | E-GEOD-63011 | biostudies-arrayexpress
TranscriptomicsAnalysis of Drosophila salivary glands and Kc cells with depleted levels of linker histone H1
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Drosophila melanogaster 
2013-04-22 | E-GEOD-44148 | biostudies-arrayexpress
UnknownHP1c regulates development and gut homeostasis by suppressing Notch signaling through Su(H).
Not available
S-EPMC8024896 | biostudies-literature
UnknownDrosophila H1 regulates the genetic activity of heterochromatin by recruitment of Su(var)3-9.
Not available
S-EPMC3756538 | biostudies-literature
MetabolomicsTranscriptomic and metabolomic analyses reveal the differential accumulation of phenylpropanoids and terpenoids in hemp autotetraploid and its diploid progenitor

Background

Cannabis sativa, a dioecious plant that has been cultivated worldwide for thousands of years, is known for its secondary metabolites, especially cannabinoids, which possess several medicinal effects. In this study, we investigated the autopolyploidization effects on the biosynthes...
2023-09-21 | MTBLS6032 | MetaboLights
ProteomicsProteomics analysis of the membrane vesicles in Pseudomonas aeruginosa under X-ray irradiation
Pseudomonas aeruginosa, X-ray irradiation, inner membrane blebbing, membrane vesicles Almost all bacteria produce membrane vesicles (MVs) that have been found to be generally composed of lipopolysaccharides (LPSs), phospholipids (PLs), outer membrane proteins, periplasmic proteins and peptidoglycan ...
ORGANISM(S): Pseudomonas aeruginosa PAO1 
2025-08-25 | PXD037062 | Pride
X-ray irradiation Membrane vesicles Proteomics analysis Pseudomonas aeruginosa 
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