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THO/TREX is a conserved nuclear complex that functions in mRNP biogenesis and prevents transcription-associated recombination. Whether or not it has a ubiquitous role in the genome is an open question. ChIP-chip studies reveal that the Hpr1 component of THO and the Sub2 RNA-dependent ATPase have gen...
ORGANISM(S): Saccharomyces cerevisiae 
Red blood cell (RBC) invasion by malaria merozoites involves formation of a parasitophorous vacuole into which the parasite moves. The vacuole membrane then seals and pinches off behind the parasite through an unknown mechanism, enclosing it within the RBC. During invasion, several merozoite surface...
ORGANISM(S): Homo sapiens (Human) Plasmodium falciparum (isolate 3D7) 
2020-11-27 | PXD021843 | Pride
Transcriptome analysis of Sub2 knockdown in African trypanosomes
THO/TREX is a conserved nuclear complex that functions in mRNP biogenesis and prevents transcription-associated recombination. Whether or not it has a ubiquitous role in the genome is an open question. ChIP-chip studies reveal that the Hpr1 component of THO and the Sub2 RNA-dependent ATPase have gen...
ORGANISM(S): Saccharomyces cerevisiae 
2011-06-29 | GSE24960 | GEO
Sub2, part of the mRNA QC system, was knocked down using RNAi. Total RNA was extracted and sequenced at BGI at three timepoints; zero, 24 and 48 hours post induction.
ORGANISM(S): Trypanosoma brucei TREU927 
THO/TREX is a conserved nuclear complex that functions in mRNP biogenesis at the interface of transcription-RNA export with a key role in preventing transcription-associated genome instability. We used microarrays to analyze the impact of different THO/TREX mutations on gene expression and found tha...
ORGANISM(S): Saccharomyces cerevisiae 
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