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MetabolomicsSubcellular antibiotic visualization reveals a dynamic drug reservoir in infected macrophages
Tuberculosis, caused by the intracellular pathogen Mycobacterium tuberculosis, remains the world's deadliest infectious disease. Sterilizing chemotherapy requires at least 6 months of multidrug therapy. Difficulty visualizing the subcellular localization of antibiotics in infected host cells means t...
2020-12-07 | MTBLS959 | MetaboLights
MetabolomicsImpact of insulin deprivation and treatment on sphingolipid distribution in different muscle subcellular compartments of streptozotocin-diabetic C57Bl/6 mice
Not available
ORGANISM(S): Mus musculus 
ST000115 | MetabolomicsWorkbench
TranscriptomicsSmall RNAs subcellular distribution in breast cancer and normal cell lines
We detect the small RNAs subcellular distribution in breast cancer cell lines MCF-7 and MDA-MB-231, and normal cell line MCF-10A. Each cell line, we detected the nuclear and cytoplasmic small RNAs expression intensity; and then we could get the nuclear-cytoplasmic-ratio.
ORGANISM(S): Homo sapiens 
2010-05-18 | E-GEOD-15937 | biostudies-arrayexpress
TranscriptomicsDeep Sequencing of Human Nuclear and Cytoplasmic Small RNAs Reveals an Unexpectedly Complex Subcellular Distribution of miRNAs and tRNA 3' Trailers
Background: MicroRNAs (miRNAs) are 22-nt small non-coding regulatory RNAs that have generally been considered to regulate gene expression at the post-transcriptional level in the cytoplasm. However, recent studies have reported that some miRNAs localize to and function in the nucleus. Methodology/Pr...
ORGANISM(S): Homo sapiens 
2010-07-14 | E-GEOD-22918 | biostudies-arrayexpress
TranscriptomicsSubcellular distribution of RNAs in HeLa cells
HeLa cells were fractioned in nucleus and cytoplasm to investigate the subcellular distribution of lncRNAs. Two-condition experiment, nuclear fraction vs. cytoplasmatic fraction from HeLa cells. Biological replicates: 2 with dye-swap
ORGANISM(S): Homo sapiens 
2015-06-30 | E-GEOD-62985 | biostudies-arrayexpress
TranscriptomicsSubcellular distribution of RNAs in HeLa cells
HeLa cells were fractioned in nucleus and cytoplasm to investigate the subcellular distribution of lncRNAs.
ORGANISM(S): Homo sapiens 
2015-06-30 | GSE62985 | GEO
GenomicsCircular RNA profiling reveals the different distribution/characteristic and possible transport mechanism among the subcellular fractions
Circular RNA profiling reveals the different distribution/characteristic and possible transport mechanism among the subcellular fractions
PRJNA419198 | ENA
ProteomicsSimultaneous characterisation of RNA and protein subcellular dynamics
Existing methods to analyse RNA localisation are constrained to specific RNAs or subcellular niches, precluding the cell-wide mapping of RNA. We present Localisation of RNA (LoRNA), which maps, at once, RNAs to membranous (nucleus, ER and mitochondria) and membraneless compartments (cytosol, nucleol...
ORGANISM(S): Homo sapiens (Human) 
2022-01-25 | PXD030456 | Pride
Dynamics Subcellular localisation Tmt Spatial-proteome Lopit 
TranscriptomicsSubcellular expression profiling of the growth cones of retinal ganglion cells (RGC)
Cue-directed axon guidance depends partly on local translation in growth cones. Many mRNA transcripts are known to reside in developing axons yet little is known about their subcellular distribution or, specifically, which transcripts are in growth cones. Laser capture microdissection (LCM) was used...
ORGANISM(S): Xenopus laevis 
2010-11-23 | E-GEOD-25166 | biostudies-arrayexpress
TranscriptomicsSmall RNA deep sequencing of cellular subcompartments
RNA deep sequencing efforts have revealed abundant expression of small RNAs derived from small nucleolar (sno) RNAs. We employ here spatial RNA deep sequencing to assess the expression of 10-40 nt small RNAs in subcellular compartments of HeLa cells. Total cellular, cytoplasmic, nuclear and nucleola...
ORGANISM(S): Homo sapiens 
2014-05-07 | E-GEOD-50057 | biostudies-arrayexpress
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