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Oral microbial homeostasis is a key factor affecting oral health, and saliva plays a significant role in maintaining oral microbial homeostasis. The submandibular gland (SMG) and sublingual gland (SLG) together produce the most saliva at rest. Organic ingredients, including antimicrobial proteins, a...
ORGANISM(S): Mus musculus (Mouse) 
2023-01-03 | PXD038423 | Pride
In order to explore the functions of carbonic anhydrase VI (CAVI) more fully, we examined the transcriptomic responses to CAVI deficiency in the submandibular gland, stomach, and duodenum of Car6-/- mice by cDNA microarray. 94, 56, and 127 genes were up- or down-regulated in the above-mentioned tiss...
ORGANISM(S): Mus musculus 
Prior to the onset of autoimmune destruction, type 1 diabetic patients and an animal model thereof, the nonobese diabetic (NOD) mouse, show morphological and functional abnormalities in target organs, which may act as inciting events for leukocyte infiltration. To better understand these abnormaliti...
ORGANISM(S): Mus musculus 
Salivary gland hypofunction lacks effective regenerative treatment, and organ-specific decellularized extracellular matrix scaffolds represent a promising biomaterial platform for tissue engineering. In this study, rat submandibular glands were decellularized using a rapid S3T1 workflow consisting o...
ORGANISM(S): Rattus norvegicus (Rat) 
2026-04-21 | PXD077315 | Pride
Prostatic acid phosphatase is the main acid phosphatase in mouse submandibular salivary gland
ORGANISM(S): Mus musculus 
To compare the gene expression profile of submandibular gland stem cells to submandibular gland epithelia, we have employed whole genome microarray expression profiling as a discovery platform to identify genes with the differential expression in the stem cells and the non-stem cell epithelia. Murin...
ORGANISM(S): Mus musculus 
Gene expression profiling and sialadenitis scoring in submandibular salivary glands from mice congenic for the two chromosomal regions Nss1 and Idd5.
ORGANISM(S): Mus musculus 
MyD88 is an important adaptor protein for signal transduction downstream of Toll-like receptors and TACI, receptors for regulation of innate immunity and B cell responses, respectively. The surfaces of oral mucosa are protected from infections by antimicrobial proteins and natural immunoglobulins th...
ORGANISM(S): Mus musculus 
RNA-Seq reveals heterogeneity in the submandibular glands and submandibular gland draining lymph nodes of SS mice
The goal of this study was to generate a spatiotemporal atlas of gene expression in the developing salivary gland. This will allow us to identify changes in gene expression that may result in the formation of the different domains of the salivary gland. At least 4 microarrays per location per time ...
ORGANISM(S): Mus musculus 
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