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ProteomicsDevelopment of Substrate-Directed Activity-Based Probes via Disulfide-Trapping for Site-Specific Interrogation of Nucleosomal Deubiquitination
Activity-based ubiquitin probes (Ub-ABPs) have been instrumental in interrogating deubiquitinases (DUBs), yet conventional Ub-ABPs lack the substrate-specific and site-specific contextual cues required to investigate nucleosomal DUBs, whose activity is tightly regulated by the chromatin environments...
ORGANISM(S): Homo Sapiens 
2025-12-30 | PXD072417 |
ProteomicsA substrate trapping approach identifies proteins regulated by reversible S-nitrosylation
In this study we adapted the Trx trapping strategy for global profiling of cellular nitrosylation/denitrosylation processes. Using this approach, we report the identification of hundreds of potential new nitrosylated targets in monoctyes and macrophages followed by validation using biochemical and f...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2014-07-02 | PXD001001 | Pride
Proteomics Human S-nitrosylation 
UnknownHDAC1 Substrate Profiling Using Proteomics-Based Substrate Trapping.
Not available
S-EPMC6563814 | biostudies-literature
UnknownOptimal Substrate-Trapping Mutants to Discover Substrates of HDAC1.
Not available
S-EPMC6858619 | biostudies-literature
UnknownHDAC6 Substrate Discovery Using Proteomics-Based Substrate Trapping: HDAC6 Deacetylates PRMT5 to Influence Methyltransferase Activity.
Not available
S-EPMC8939004 | biostudies-literature
ProteomicsMurine CLPP protease substrate trapping in MEF cells
Classic susbtrate-trapping screen for ClpXP substrates using MEF cell lines overexpressing FLAG-tagged CLPP (WT), proteolytically inactive CLPP (TRAP) or vector control (NEG)
ORGANISM(S): Mus musculus (Mouse) 
2020-06-01 | PXD015399 | Pride
Interactor Mouse Cllp protease Substrate Trap experiment Cell line 
UnknownTrapping the substrate radical of heme synthase AhbD.
Not available
S-EPMC11306076 | biostudies-literature
UnknownCoupling substrate-trapping with proximity-labeling to identify protein tyrosine phosphatase PTP1B signaling networks.
Not available
S-EPMC10148153 | biostudies-literature
ProteomicsProlyl Hydroxylase Substrate Adenylosuccinate Lyase Is An Oncogenic Driver In Triple Negative Breast Cancer
Protein hydroxylation extensively regulates cellular signaling by affecting protein stability, protein-protein interaction and protein activity, and its dysregulation contributes to the pathogenesis of various diseases including cancers. However, because of the transient nature of the enzyme-substra...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-10-02 | MSV000086231 | MassIVE
UnknownA substrate-trapping strategy for protein phosphatase PP1 holoenzymes using hypoactive subunit fusions.
Not available
S-EPMC6166715 | biostudies-literature
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