A substrate trapping approach identifies proteins regulated by reversible S-nitrosylation
Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap
ORGANISM(S): Homo Sapiens (human) Mus Musculus (mouse)
TISSUE(S): B Cell
SUBMITTER: 
Tamar Ziv
LAB HEAD: Moran Benhar
PROVIDER: PXD001001 | Pride | 2014-07-02
REPOSITORIES: Pride
Publications
A substrate trapping approach identifies proteins regulated by reversible S-nitrosylation.
Ben-Lulu Shani S Ziv Tamar T Admon Arie A Weisman-Shomer Pnina P Benhar Moran M
Molecular & cellular proteomics : MCP 20140627 10
Protein S-nitrosylation, the nitric oxide-mediated posttranslational modification of cysteine residues, has emerged as an important regulatory mechanism in diverse cellular processes. Yet, knowledge about the S-nitrosoproteome in different cell types and cellular contexts is still limited and many questions remain regarding the precise roles of protein S-nitrosylation and denitrosylation. Here we present a novel strategy to identify reversibly nitrosylated proteins. Our approach is based on nitr ...[more]
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