Sort   by:  
 Page size 
TranscriptomicsReactivation of multipotency by oncogenic PIK3CA induces breast tumor heterogeneity
Breast cancer is the most frequent cancer in women and consists of heterogeneous types of tumours that are classified into different histological and molecular subtypes1-3. Pik3ca and p53 are the two most frequently mutated genes and are associated with different types of human breast cancers4. The ...
ORGANISM(S): Mus musculus 
2015-08-13 | E-GEOD-69290 | biostudies-arrayexpress
GenomicsSingle-Cell Whole-Genome Bisulfite Sequencing for Analysis of Epigenetic Heterogeneity
We report a single-cell whole-genome bisulfite sequencing method (scBS-Seq) capable of accurately measuring DNA methylation at up to 36% of CpGs. We observed that ESCs grown in serum/LIF or 2i/LIF both display epigenetic heterogeneity, with M-bM-^@M-^\2i-likeM-bM-^@M-^] cells present in serum cultur...
ORGANISM(S): Mus musculus 
2014-07-18 | E-GEOD-56879 | biostudies-arrayexpress
ProteomicsOne-Pot Isotope Dilution PRM for Quantitative Protein Heterogeneity in Red Blood Cells
Single cell and low-input cell proteomics to measure cellular heterogeneity remains experimental and requires further refinement for routine application. This study aimed to build on previous protocols to assess the utility of targeted proteomics for measuring heterogeneity in red blood cells (RBCs)...
ORGANISM(S): Homo Sapiens 
2024-02-06 | PXD030875 | panorama
ProteomicsTargeted protein degradation reveals Pol II heterogeneity and functional diversity
RNA polymerase II (Pol II) subunits are thought to be involved in various transcription-associated processes, but it is unclear whether they play different regulatory roles in modulating gene expression. Here, we performed nascent and mature transcript sequencing after the acute degradation of 12 ma...
ORGANISM(S): Mus <genus> 
2022-08-09 | PXD035866 |
ProteomicsProtein-level evidence of novel β-type hemocyanin and heterogeneous subunit usage in the Pacific whiteleg shrimp, Litopenaeus vannamei
The functional diversity of crustacean hemocyanins is broad, encompassing O2 delivery, innate immune response, metabolite storage, and osmolyte balance, all in a heterogeneous protein structure. As such, the sequence diversity of this class of proteins and its subunit composition are the focus of ma...
ORGANISM(S): Penaeus vannamei 
2020-02-07 | PXD014575 | Pride
Proteomics Subunit heterogeneity Mass spectrometry Hemocyanin Crustacean 
UnknownRevealing charge heterogeneity of stressed trastuzumab at the subunit level.
Not available
S-EPMC9974696 | biostudies-literature
ProteomicsStructural O-Glycoform Heterogeneity of the SARS-CoV-2 Spike Protein Receptor-Binding Domain Revealed by Top-Down Mass Spectrometry
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) utilizes an extensively glycosylated surface spike (S) protein to mediate host cell entry and the S protein glycosylation plays key roles in altering viral binding/function and infectivity. However, the molecular structures and glycan hete...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-07-27 | MSV000087891 | MassIVE
TranscriptomicsMicrovascular endothelial heterogeneity
The goal of this study was to gain insight into the molecular heterogeneity of capillary endothelial cells derived from different organs by microarray profiling of freshly isolated cells and identify transcription factors that may determine the specific gene expression profile of endothelial cells f...
ORGANISM(S): Mus musculus 
2015-02-19 | E-GEOD-48209 | biostudies-arrayexpress
TranscriptomicsTranscriptional hallmarks of heterogeneous neural stem cell niches of the subventricular zone.
Throughout postnatal life in mammals, neural stem cells (NSCs) are located in the subventricular zone (SVZ) of the lateral ventricles. The greatest diversity of neuronal and glial lineages they generate occurs during early postnatal life in a region-specific manner. In order to evaluate potential he...
ORGANISM(S): Mus musculus 
2015-04-07 | E-GEOD-60905 | biostudies-arrayexpress
TranscriptomicsHeterogeneity of Breast Cancer Vasculature
Tumor-associated breast vasculature was laser-cappture microdissected from IDC breast cancer cases. The goal of the study was to characterize the heterogeneity of breast tumor-associated vasculature and identify gene expression signatures predictive of clinical outcome. common reference design, 32 s...
ORGANISM(S): Homo sapiens 
2010-09-19 | E-GEOD-15363 | biostudies-arrayexpress
Sort   by:  
 Page size