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TranscriptomicsAspp1 Preserves Hematopoietic Stem Cell Pool Integrity and Prevents Malignant Transformation
Quiescent hematopoietic stem cells (HSCs) are prone to mutagenesis, and accumulation of mutations can result in hematological malignancies. The mechanisms through which HSCs prevent such detrimental accumulation, however, are unclear. Here, we show that Aspp1 coordinates with p53 to maintain the gen...
ORGANISM(S): Mus musculus 
2015-05-20 | E-GEOD-69032 | biostudies-arrayexpress
TranscriptomicsTracing the conversion process for primordial germ cells to pluripotent stem cells
The overall gene expression profiles revealed by this system provide novel insight into how pluripotency is acquired in germ-committed cells. In the study presented here, we employed FACS sorting to purify pluripotent candidate cells during the culture period
ORGANISM(S): Mus musculus 
2012-04-24 | E-GEOD-37261 | biostudies-arrayexpress
TranscriptomicsGene expression profile of zebrafish renal collecting ducts
The kidney is the main hematopoietic organ in teleost fish. Various stages of hematopoietic cells were observed in the interstitial tissue of the kidney. We recently demonstrated that zebrafish hematopoietic stem cells (HSCs) expressing jam1a were specifically localized along the renal collecting du...
ORGANISM(S): Danio rerio 
2012-08-24 | E-GEOD-32363 | biostudies-arrayexpress
TranscriptomicsGene expression profile of murine bone marrow endosteal populations (2)
A subset of osteoblasts functions as a key component of the hematopoietic stem cell niche. But it is still unclear that the precise cellular and molecular contribution of endosteal cell populations on the HSC supportive microenvironment. We purified the endosteal cells and subdivided them into mesen...
ORGANISM(S): Mus musculus 
2010-08-10 | E-GEOD-17570 | biostudies-arrayexpress
TranscriptomicsGene expression profile of murine bone marrow endosteal populations (1)
A subset of osteoblasts functions as a key component of the hematopoietic stem cell niche. But it is still unclear that the precise cellular and molecular contribution of endosteal cell populations on the HSC supportive microenvironment. We purified the endosteal cells and subdivided them into mesen...
ORGANISM(S): Mus musculus 
2010-08-10 | E-GEOD-17569 | biostudies-arrayexpress
TranscriptomicsBacterial c-di-GMP reorganizes hematopoietic stem/progenitors and niches through STING
Upon systemic bacterial infection, hematopoietic stem and progenitor cells (HSPCs) migrate to the periphery in order to supply a sufficient number of immune cells. Although pathogen-associated molecular patterns (PAMPs) reportedly mediate HSPC activation, how HSPCs detect pathogen invasion in vivo r...
ORGANISM(S): Mus musculus 
2015-02-13 | E-GEOD-65905 | biostudies-arrayexpress
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