Sort   by:  
 Page size 
TranscriptomicsKDM2B links the Polycomb Repressive Complex 1 (PRC1) to recognition of CpG islands
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2012-12-26 | E-GEOD-41267 | biostudies-arrayexpress
GenomicsKDM2B binds CpG islands and modulates recruitment of Ring1b
CpG island elements are associated with most mammalian gene promoters, yet how they contribute to gene regulation remains poorly understood. Recently it has become clear that a subset of CpG islands in embryonic stem cells can act as polycomb response elements and are recognized by the polycomb sile...
ORGANISM(S): Mus musculus 
2012-12-26 | E-GEOD-40860 | biostudies-arrayexpress
TranscriptomicsGene expression changes following knockdown of Kdm2b on mESCs
In order to study the effects of Kdm2b binding at CpG islands, Kdm2b was knocked down in mouse embryonic stem cells using shRNA and gene expression profiled using Affymetrix arrays Depletion of KDM2B affects the gene expression of a subset of polycomb targets RNA from 4 samples stably expressing shK...
ORGANISM(S): Mus musculus 
2012-12-26 | E-GEOD-40701 | biostudies-arrayexpress
TranscriptomicsThe Wnt/β-catenin-signaling pathway is modulated by androgen ablation therapy for advanced clinical prostate cancer and contributes to androgen independent cell growth
Androgen ablation therapy (AAT) is standard treatment for locally-advanced/metastatic prostate cancer (PCa). Many patients develop castration-resistance (CRPCa) after ~2-3 years, with a poor prognosis. The molecular mechanisms underlying CRPCa progression are unclear. mRNA-Seq was performed on tu...
ORGANISM(S): Homo sapiens 
2013-10-07 | E-GEOD-48403 | biostudies-arrayexpress
TranscriptomicsNext generation sequencing of advanced non-castrate prostate cancer treated with docetaxel chemotherapy
Early chemotherapy for advanced/metastatic non-castration resistant prostate cancer (PCa) may improve overall patient survival. We studied the safety, tolerability and early efficacy of up-front docetaxel chemotherapy and androgen deprivation therapy (ADT) versus ADT alone for patients with newly-d...
ORGANISM(S): Homo sapiens 
2014-09-18 | E-GEOD-51005 | biostudies-arrayexpress
TranscriptomicsGenotyping of human family trios using placental cDNA, placental genomic DNA (gDNA) and gDNA from both parents to find new imprinted genes
Twenty-three family trios of placental cDNA, placental genomic DNA (gDNA) and gDNA from both parents were tested using Illumina SNP arrays to find new imprinted genes to ascertain the extent of allele specific expression in this tissue.
ORGANISM(S): Homo sapiens 
2010-04-15 | E-TABM-796 | biostudies-arrayexpress
Sort   by:  
 Page size