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TranscriptomicsExpression data from isogenic Pten WT mouse T-ALLs infected with MSCV Myr-AKT-IRES-mCherry or empty vector, treated with DBZ or DMSO
To explore the mechanisms downstream of NOTCH1 and PTEN in the control of leukemia cell growth, we performed expression profiling on NOTCH1 induced and Pten-positive T-ALL tumor cells infected with constitutively active AKT (myristoylated-AKT). Constitutive activation of AKT rescues the transcriptio...
ORGANISM(S): Mus musculus 
2015-08-31 | E-GEOD-71089 | biostudies-arrayexpress
TranscriptomicsExpression data from isogenic Pten WT or KO mouse T-ALLs treated with DBZ or DMSO
To investigate the underlying mechanisms mediating resistance to NOTCH inhibition in Pten-null T-ALL tumor cells we performed gene expression profiling of isogenic Pten-positive and Pten-deleted leukemia lymphoblasts after acute treatment with DBZ in vivo. This analysis revealed that, while direct N...
ORGANISM(S): Mus musculus 
2015-08-31 | E-GEOD-71087 | biostudies-arrayexpress
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